ArticleBiodemography and social biology2013
Development and evaluation of a genetic risk score for obesity.
Article in Biodemography and social biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.Behavior genetics · 2021Pooled it
- Genetic and physiological insights into satiation variability predict responses to obesity treatment.Cell metabolism · 2025Trial
- Pathway-Based Genetic Risk Scores Are Associated with Blood Lipids Among Young Mexican Adults.Nutrients · 2026Article
- Applicability of the New Zealand-eating behavior questionnaire to predict weight loss responses to naltrexone/bupropion: a proof-of-concept trial.Obesity pillars · 2026Article
- Multimodal (Bio)Markers and Risk of Obesity - A Comprehensive Scoping Review.Advances in nutrition (Bethesda, Md.) · 2026Article
- Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES - 165].PloS one · 2026Article
- Genetic Variants in Metabolic Pathways and Their Role in Cardiometabolic Risk: An Observational Study of >4000 Individuals.Biomedicines · 2025Article
- Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study.Scientific reports · 2025Article
- Elucidating the Role of Estrogen Effects in Leukemia: Insights from Single-Cell RNA Sequencing and Mendelian Randomization.Journal of Cancer · 2025Article
- Mapping the relative accuracy of cross-ancestry prediction.Nature communications · 2024Article
- Obesity risk in young adults from the Jerusalem Perinatal Study (JPS): the contribution of polygenic risk and early life exposure.International journal of obesity (2005) · 2024Article
- Investigation of the interaction between genetic risk score (GRS) and fatty acid quality indices on metabolic syndrome among overweight and obese women.BMC medical genomics · 2024Article
- Deciphering the Interplay between Genetic Risk Scores and Lifestyle Factors on Individual Obesity Predisposition.Nutrients · 2024Article
- Overestimated prediction using polygenic prediction derived from summary statistics.BMC genomic data · 2023Article
- Ethnic disparities in fracture risk assessment using polygenic scores.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Observational
- Development of a genetic risk score for obesity predisposition evaluation.Molecular genetics and genomics : MGG · 2022Article
- Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women.Diabetology & metabolic syndrome · 2022Article
- Polygenic risk scores for CARDINAL study.Nature genetics · 2022Article
- Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Human molecular genetics · 2022Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Multi-locus profiles of genetic risk, so-called "genetic risk scores," can be used to translate discoveries from genome-wide association studies into tools for population health research. We developed a genetic risk score for obesity from results of 16 published genome-wide association studies of obesity phenotypes in European-descent samples. We then evaluated this genetic risk score using data from the Atherosclerosis Risk in Communities (ARIC) cohort GWAS sample (N = 10,745, 55% female, 77% white, 23% African American). Our 32-locus GRS was a statistically significant predictor of body mass index (BMI) and obesity among ARIC whites [for BMI, r = 0.13, p<1 × 10(-30); for obesity, area under the receiver operating characteristic curve (AUC) = 0.57 (95% CI 0.55-0.58)]. The GRS predicted differences in obesity risk net of demographic, geographic, and socioeconomic information. The GRS performed less well among African Americans. The genetic risk score we derived from GWAS provides a molecular measurement of genetic predisposition to elevated BMI and obesity.[Supplemental materials are available for this article. Go to the publisher's online edition of Biodemography and Social Biology for the following resource: Supplement to Development & Evaluation of a Genetic Risk Score for Obesity.].
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