ArticleBiodemography and social biology2013
Beyond orchids and dandelions: testing the 5-HTT "risky" allele for evidence of phenotypic capacitance and frequency-dependent selection.
Article in Biodemography and social biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Genetic influences on depression and selection into adverse life experiences.Social science & medicine (1982) · 2024Article
- Human resilience depends on distinctively human brain circuitry and development.Frontiers in behavioral neuroscience · 2024Article
- The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Opportunities and challenges of big data for the social sciences: The case of genomic data.Social science research · 2016Article
- Behavioral idiosyncrasy reveals genetic control of phenotypic variability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- To cause or not to cause? That is the question, but identical twins might not have all of the answers.Social science & medicine (1982) · 2015Article
- The interactive effect of neighborhood peer cigarette use and 5HTTLPR genotype on individual cigarette use.Addictive behaviors · 2014Article
- The long arm of adolescence: school health behavioral environments, tobacco and alcohol co-use, and the 5HTTLPR gene.Biodemography and social biology · 2014Article
- Genetic sensitivity to peer behaviors: 5HTTLPR, smoking, and alcohol consumption.Journal of health and social behavior · 2013Article
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Authors and funding
3 authors.
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Abstract
The persistence of behaviorally deleterious genes in the human population poses an interesting question for population genetics: If certain alleles at these loci are deleterious, why have they survived in the population? We consider evidence for phenotypic capacitance and/or frequency-dependent selection for an allele that has been putatively shown to have negative associations with human behaviors (the "short" 5-HTT promoter region allele) yet has persisted in human and nonhuman primate populations. Using data from the National Longitudinal Study of Adolescent Health, we compare sibling and twin variation in depression by 5-HTT genotype (specified in several ways) and investigate sibship-level cross-person gene-gene interactions. In support of the "orchid/dandelion" hypothesis, we find evidence that the short allele increases variation in phenotypes in response to environmental (or genetic) differences (i.e., acts as a perturbation of a phenotypic capacitor). Further, we also find some evidence that the effects of allelic variation at this locus are moderated by the genetic environment of the sibship unit (i.e., effects may be susceptible to frequency-dependent selection). We discuss implications of these findings for genetic models in general, specifically with respect to stable unit treatment value assumption violations (i.e., nonindependence of units of analysis).
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