Evidence map›Paper›PMID 23701321›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2013

Diagnosing autism spectrum disorder: who will get a DSM-5 diagnosis?

Rachel G Kent, Sarah J Carrington, Ann Le Couteur, Judith Gould, Lorna Wing, Jarymke Maljaars, Ilse Noens, Ina van Berckelaer-Onnes, Susan R Leekam

Open access · hybridAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  6. Reliability of the Commonly Used and Newly-Developed Autism Measures.Journal of autism and developmental disorders · 2024
    Article
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  16. Early Autism Screening: A Comprehensive Review.International journal of environmental research and public health · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Rachel G KentWales Autism Research Centre, School of Psychology, Cardiff University, Cardiff, UK.
Sarah J Carrington
Ann Le Couteur
Judith Gould
Lorna Wing
Jarymke Maljaars
Ilse Noens
Ina van Berckelaer-Onnes
Susan R Leekam
Cardiff University · GBKU Leuven · BEThe National Autistic Society · GBLeiden University · NLNewcastle University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntroduction of proposed criteria for DSM-5 Autism Spectrum Disorder (ASD) has raised concerns that some individuals currently meeting diagnostic criteria for Pervasive Developmental Disorder (PDD; DSM-IV-TR/ICD-10) will not qualify for a diagnosis under the proposed changes. To date, reports of sensitivity and specificity of the new criteria have been inconsistent across studies. No study has yet considered how changes at the 'sub domain' level might affect overall sensitivity and specificity, and few have included individuals of different ages and ability levels.

methodsA set of DSM-5 ASD algorithms were developed using items from the Diagnostic Interview for Social and Communication Disorders (DISCO). The number of items required for each DSM-5 subdomain was defined either according to criteria specified by DSM-5 (Initial Algorithm), a statistical approach (Youden J Algorithm), or to minimise the number of false positives while maximising sensitivity (Modified Algorithm). The algorithms were designed, tested and compared in two independent samples (Sample 1, N = 82; Sample 2, N = 115), while sensitivity was assessed across age and ability levels in an additional dataset of individuals with an ICD-10 PDD diagnosis (Sample 3, N = 190).

resultsSensitivity was highest in the Initial Algorithm, which had the poorest specificity. Although Youden J had excellent specificity, sensitivity was significantly lower than in the Modified Algorithm, which had both good sensitivity and specificity. Relaxing the domain A rules improved sensitivity of the Youden J Algorithm, but it remained less sensitive than the Modified Algorithm. Moreover, this was the only algorithm with variable sensitivity across age. All versions of the algorithm performed well across ability level.

conclusionsThis study demonstrates that good levels of both sensitivity and specificity can be achieved for a diagnostic algorithm adhering to the DSM-5 criteria that is suitable across age and ability level.

Indexed as

AlgorithmsDiagnostic and Statistical Manual of Mental DisordersAdolescentAdultAge FactorsChildChild Development Disorders, PervasiveChild, PreschoolFemaleHumansInternational Classification of DiseasesMaleSensitivity and SpecificityYoung AdultASDdiagnosisDISCODSM-5

Identifiers

PMID23701321
PMCPMC4098079
OpenAlexW2108924157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.