ArticleJournal of the American Chemical Society2013
Differential impact of β and γ residue preorganization on α/β/γ-peptide helix stability in water.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Foldamers controlled by functional triamino acids: structural investigation of α/γ-hybrid oligopeptides.Communications chemistry · 2024Article
- Hormone Analogues with Unique Signaling Profiles from Replacement of α-Residue Triads with β/γ Diads.Journal of the American Chemical Society · 2023Article
- De Novo Left-Handed Synthetic Peptidomimetic Foldamers.Angewandte Chemie (International ed. in English) · 2018Article
- Impact of Backbone Pattern and Residue Substitution on Helicity in α/β/γ-Peptides.Journal of the American Chemical Society · 2018Article
- Right-Handed Helical Foldamers Consisting of De Novo d-AApeptides.Journal of the American Chemical Society · 2017Article
- An α-Helix-Mimicking 12,13-Helix: Designed α/β/γ-Foldamers as Selective Inhibitors of Protein-Protein Interactions.Angewandte Chemie (International ed. in English) · 2016Article
- Impact of γ-Amino Acid Residue Preorganization on α/γ-Peptide Foldamer Helicity in Aqueous Solution.Journal of the American Chemical Society · 2016Article
- Evaluation of a cyclopentane-based γ-amino acid for the ability to promote α/γ-peptide secondary structure.The Journal of organic chemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ residues in the context of a specific α/β/γ-peptide helix. The results show that β residue preorganization is critical for helix stability but that γ residue preorganization is less important.
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Registered trials
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