ArticleThe New phytologist2013
The glutathione transferase of Nicotiana benthamiana NbGSTU4 plays a role in regulating the early replication of Bamboo mosaic virus.
Article in The New phytologist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Genome-wide identification of the GST reveals ZmGST1 enhances the resistance to Exserohilum turcicum in maize.BMC plant biology · 2026Article
- Bamboo mosaic virus-induced metabolic reprogramming engages mitochondrial function to regulate redox homeostasis and defense responses in Nicotiana benthamiana.BMC plant biology · 2025Article
- Role of the Transcription Factor NbTFIISL in Enhancing Bamboo Mosaic Virus Accumulation via Mitochondria Localisation.Molecular plant pathology · 2025Article
- Proviral insights of glycolytic enolase inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Capsicum chinense Jacq.-derived glutaredoxin (CcGRXS12) alters redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I).Plant cell reports · 2024Article
- Glutathione-the "master" antioxidant in the regulation of resistant and susceptible host-plant virus-interaction.Frontiers in plant science · 2024Review
- Glutathione Contribution in Interactions betweenInternational journal of molecular sciences · 2023Article
- AtGSTU19 and AtGSTU24 as Moderators of the Response ofInternational journal of molecular sciences · 2022Article
- The gibberellic acid derived from the plastidial MEP pathway is involved in the accumulation of Bamboo mosaic virus.The New phytologist · 2022Article
- Glutathione Modulation in PVYInternational journal of molecular sciences · 2022Article
- The Role of Plant Growth Promoting Rhizosphere Microbiome as Alternative Biofertilizer in BoostingPlants (Basel, Switzerland) · 2022Article
- Voltage-dependent anion channel proteins associate with dynamic Bamboo mosaic virus-induced complexes.Plant physiology · 2022Article
- Reactive oxygen species-related genes participate in resistance to cucumber green mottle mosaic virus infection regulated by boron inFrontiers in plant science · 2022Article
- NbPsbO1 Interacts Specifically with theJournal of virology · 2021Article
- Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication.The EMBO journal · 2021Article
- Review
- dsRNA Molecules From theFrontiers in plant science · 2021Article
- The Lipid Transfer Protein 1 fromViruses · 2020Article
- Article
- Glutathione S-transferase: a versatile protein family.3 Biotech · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bamboo mosaic virus (BaMV) is a single-stranded positive-sense RNA virus. One of the plant glutathione S-transferase (GST) genes, NbGSTU4, responds as an upregulated gene in Nicotiana benthamiana post BaMV infection. In order to identify the role of NbGSTU4 in BaMV infection, the expression of NbGSTU4 was knocked down using a virus-induced gene silencing technique or was transiently expressed in N. benthamiana in BaMV inoculation. The results show a significant decrease in BaMV RNA accumulation when the expression level of NbGSTU4 is reduced; whereas the viral RNA accumulation increases when NbGSTU4 is transiently expressed. Furthermore, this study identified that the involvement of NbGSTU4 in viral RNA accumulation occurs by its participation in the viral early replication step. The findings show that the NbGSTU4 protein expressed from Escherichia coli can interact with the 3' untranslated region (UTR) of the BaMV RNA in vitro in the presence of glutathione (GSH). The addition of GSH in the in vitro replication assay shows an enhancement of minus-strand but not plus-strand RNA synthesis. The results suggest that the plant GST protein plays a role in binding viral RNA and delivering GSH to the replication complex to create a reduced condition for BaMV minus-strand RNA synthesis.
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