ArticleInfection and immunity1990
Isotypic profiles of antibody responses to Toxoplasma gondii infection in rats and mice: kinetic study and characterization of target antigens of immunoglobulin A antibodies.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Purification and Characterization of Immunoglobulin Y (IgY) Targeting Surface Antigen 1 (SAG1) ofAntibodies (Basel, Switzerland) · 2025Article
- AmBio · 2019Article
- DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice.Parasites & vectors · 2014Article
- A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.PLoS pathogens · 2014Article
- Kinetics and time dependence of the differential agglutination of acetone [AC]- and formalin [HS]-fixed Toxoplasma tachyzoites by serum of mice with experimental toxoplasmosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2012Article
- Immunogenic characterization of the chimeric surface antigen 1 and 2 (SAG1/2) of Toxoplasma gondii expressed in the yeast Pichia pastoris.Parasitology research · 2011Article
- Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells.Infection and immunity · 2005Article
- Monoclonal rat antibodies directed against Toxoplasma gondii suitable for studying tachyzoite-bradyzoite interconversion in vivo.Clinical and diagnostic laboratory immunology · 1995Article
- Kinetics study and characterisation of target excreted/secreted antigens of immunoglobulin G, M, A and E antibodies from mice infected with different strains of Toxoplasma gondii.Parasitology research · 1994Article
- Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection.Infection and immunity · 1993Article
- IgA antibody response during acquired and congenital toxoplasmosis.Journal of clinical pathology · 1992Article
- Identification of T cell epitopes within a 23-kD antigen (P24) of Toxoplasma gondii.Clinical and experimental immunology · 1991Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antibody responses to Toxoplasma gondii were investigated in rat and mouse experimental models. The immunoglobulin A (IgA) antibody response was of particular interest because acquisition of Toxoplasma gondii is usually by the oral route. The rat model was used because the natural resistance of rats to the parasite is similar to the natural resistance exhibited by adult humans. There was an early and simultaneous rise in IgA and IgM antibody responses. The IgA antibody response was maximal around day 40. IgA antibodies from Fischer rats were mainly directed against soluble and membrane antigens of 28.5, 29, 30, 35, and 38 kilodaltons (kDa). In mice, however, a major antigen of 29 kDa was recognized by IgA antibodies. Moreover, in orally infected rats, an intense IgE antibody response against the major surface antigen, P30, was observed. An IgA antibody response was also observed in rats and mice immunized with Toxoplasma excreted-secreted antigens, even without adjuvant. This response was mainly directed against 28.5- and 34-kDa antigens in rats. Serum IgA from infected rats tested against the excreted-secreted antigens bound to 28.5- 34-, and 39-kDa antigens, whereas sera from infected mice recognized only the 34-kDa antigen.
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