ArticleAdipocyte2012
Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location.
Article in Adipocyte, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 89 citations in OpenAlex.
- Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder.Scientific reports · 2026Trial
- Changes in Visceral Adiposity, Subcutaneous Adiposity, and Sex Hormones in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2017Trial
- Age-related changes in adiposity and cardiometabolic disease risk: a longitudinal and prospective study in the UK Biobank.International journal of obesity (2005) · 2026Article
- Attention-based graph neural network framework for non-invasive CAP score prediction in fatty liver disease via body modeling.Physical and engineering sciences in medicine · 2026Article
- Association between lipid accumulation product and asthma in US adults: evidence from the NHANES 2005-2020.BMC pulmonary medicine · 2026Article
- The UF/MSK adult mesh-based computational human phantom library: applications to organ dosimetry in computed tomography.Physics in medicine and biology · 2025Article
- Distinct metabolic associations of subcutaneous and visceral adipocyte morphology in women with or without obesity.Scientific reports · 2025Article
- Effects of Endoscopic Sleeve Gastroplasty on Body Composition and Metabolism: An InBody Analysis.Obesity surgery · 2025Article
- Perspective from NHANES data: synergistic effects of visceral adiposity index and lipid accumulation products on diabetes risk.Scientific reports · 2025Article
- Differences in Lipid Metabolism between the Perirenal Adipose Tissue of Chinese Simmental Cattle and Angus Cattle (Animals : an open access journal from MDPI · 2024Article
- Exploring the heterogeneity of hepatic and pancreatic fat deposition in obesity: implications for metabolic health.Frontiers in endocrinology · 2024Observational
- GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity.Cells · 2023Article
- Perirenal Fat Thickness is Associated with Metabolic Dysfunction-Associated Fatty Liver Disease in Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Perirenal fat thickness as a superior obesity-related marker of subclinical carotid atherosclerosis in type 2 diabetes mellitus.Frontiers in endocrinology · 2023Article
- Clinical Classification of Obesity and Implications for Metabolic Dysfunction-Associated Fatty Liver Disease and Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Review
- Differential Metabolism of Glycerol Based on Oral versus Intravenous Administration in Humans.Metabolites · 2022Article
- Effects of Dried Onion Powder and Quercetin on Obesity-Associated Hepatic Menifestation and Retinopathy.International journal of molecular sciences · 2022Article
- Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity.International journal of molecular sciences · 2022Article
- Gender differences in cardiometabolic health and disease in a cross-sectional observational obesity study.Biology of sex differences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Increased visceral adiposity is a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance and type 2 diabetes, whereas peripheral (subcutaneous) obesity is not. Though the specific mechanisms which contribute to these adipose depot differences are unknown, visceral fat accumulation is proposed to result in metabolic dysregulation because of increased effluent, e.g., fatty acids and/or adipokines/cytokines, to the liver via the hepatic portal vein. Pathological significance of visceral fat accumulation is also attributed to adipose depot/adipocyte-specific characteristics, specifically differences in structural, physiologic and metabolic characteristics compared with subcutaneous fat. Fat manipulations, such as removal or transplantation, have been utilized to identify location dependent or independent factors that play a role in metabolic dysregulation. Obesity-induced alterations in adipose tissue function/intrinsic characteristics, but not mass, appear to be responsible for obesity-induced metabolic dysregulation, thus "quality" is more important than "quantity." This review summarizes the implications of obesity-induced metabolic dysfunction as it relates to anatomic site and inherent adipocyte characteristics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.