ArticleAdipocyte2012
Of mice and men: Factors abrogating the antiobesity effect of omega-3 fatty acids.
Article in Adipocyte, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review.Nutrients · 2021Review
- The Omega-3 Fatty Acids EPA and DHA, as a Part of a Murine High-Fat Diet, Reduced Lipid Accumulation in Brown and White Adipose Tissues.International journal of molecular sciences · 2019Article
- Seafood intake and the development of obesity, insulin resistance and type 2 diabetes.Nutrition research reviews · 2019Review
- Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice.Nutrients · 2019Article
- Review
- The Anti-inflammatory Effect of Personalized Omega-3 Fatty Acid Dosing for Reducing Prostaglandin ECancer prevention research (Philadelphia, Pa.) · 2017Article
- Links between Dietary Protein Sources, the Gut Microbiota, and Obesity.Frontiers in physiology · 2017Review
- FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids.Mediators of inflammation · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of n-3 long chain polyunsaturated fatty acids (PUFAs) to prevent high fat diet-induced obesity in rodents is well documented. Evidence for a similar effect in humans is, however, limited. Intervention studies in humans are inconclusive and epidemiological studies are dichotomous. Our recent finding that sucrose and other high glycemic index carbohydrates abrogate the antiobesity effect of n-3 PUFAs might, at least in part, provide an explanation to the apparent discrepancy between human and rodent intervention studies, and the lack of effect in some human trials. In addition to the amount and type of carbohydrates, the levels of n-6 PUFAs, linoleic acid in particular, in the background diet might influence the antiobesogenic effect of n-3 PUFAs. Lastly, it is plausible that the quantity of persistent organic pollutants in fish oil, and seafood rich in n-3 PUFAs, might have an influence on the outcome of the trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.