ArticleAdipocyte2012
Depot-specific differences in adipocyte insulin sensitivity in mice are diet- and function-dependent.
Article in Adipocyte, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the therapeutic potential of extract in targeting localized adiposity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- White adipocyte dysfunction and obesity-associated pathologies in humans.Nature reviews. Molecular cell biology · 2024Review
- Uremic sarcopenia: the role of intramuscular adipose tissue as a potential early identifier.Frontiers in medicine · 2024Article
- Adipocyte traits limiting cellular insulin responsiveness and glucose transport.American journal of physiology. Endocrinology and metabolism · 2023Article
- Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.International journal of molecular sciences · 2023Article
- Of mice and men: Pinpointing species differences in adipose tissue biology.Frontiers in cell and developmental biology · 2022Review
- Depot-specific adipocyte-extracellular matrix metabolic crosstalk in murine obesity.Adipocyte · 2020Article
- Article
- The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release.Adipocyte · 2018Review
- Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells.Scientific reports · 2016Article
- Short-term HFD does not alter lipolytic function of adipocytes.Adipocyte · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fat depots of different localization vary in their biological/metabolic function. We recently provided evidence for different regulation of lipolysis between perigonadal and mesenteric adipocytes; in particular insulin-induced suppression of lipolysis was significantly higher in perigonadal compared with mesenteric adipocytes in chow-fed mice. Moreover, insulin's anti-lipolytic effect was maintained in mesenteric but lost in perigonadal adipocytes under high fat diet (HFD). Herein, we expanded our previous study and included inguinal (subcutaneous) adipocytes in our analysis. When compared with perigonadal adipocytes, inguinal adipocytes are equally sensitive to insulin's anti-lipolytic effect under chow diet. However, they remain insulin-sensitive under HFD. Moreover, insulin-stimulated glucose incorporation was equally blunted in adipocytes of all three depots in HFD-fed mice. In conclusion, regulation of insulin sensitivity in murine adipocytes is diet-, depot- and function-dependent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.