ArticlePloS one2013
Characterization of neonatal vocal and motor repertoire of reelin mutant mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency.Science advances · 2026Article
- Assessment of the effects of sex, age, and rearing condition on ultrasonic vocalizations elicited by pups during the maternal potentiation paradigm in C57BL/6J mice.Developmental psychobiology · 2022Article
- Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice.iScience · 2022Article
- Relationship between RELN signaling pathway genes and language development of autism based on a cluster model.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds.Frontiers in behavioral neuroscience · 2022Article
- Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice.Environmental health perspectives · 2021Article
- TheJournal of clinical medicine · 2019Review
- Quantifying ultrasonic mouse vocalizations using acoustic analysis in a supervised statistical machine learning framework.Scientific reports · 2019Article
- Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice.Particle and fibre toxicology · 2018Article
- INTERNEURONOPATHIES AND THEIR ROLE IN EARLY LIFE EPILEPSIES AND NEURODEVELOPMENTAL DISORDERS.Epilepsia open · 2017Article
- Behavioral Phenotyping for Autism Spectrum Disorders in Mice.Current protocols in toxicology · 2017Article
- The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.Neurobiology of disease · 2017Article
- Cry, baby, cry: Expression of Distress as a Biomarker and Modulator in Autism Spectrum Disorder.The international journal of neuropsychopharmacology · 2017Article
- The Functioning of a Cortex without Layers.Frontiers in neuroanatomy · 2017Review
- Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.Cell · 2016Article
- Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns.Scientific reports · 2016Article
- Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies.Toxics · 2015Review
- Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism.PloS one · 2015Article
- The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy.Epilepsy research and treatment · 2014Article
- From mice to men: lessons from mutant ataxic mice.Cerebellum & ataxias · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reelin is a large secreted extracellular matrix glycoprotein playing an important role in early neurodevelopment. Several genetic studies found an association between RELN gene and increased risk of autism suggesting that reelin deficiency may be a vulnerability factor in its etiology. Moreover, a reduced reelin expression has been observed in several brain regions of subjects with Autism Spectrum Disorders. Since a number of reports have documented presence of vocal and neuromotor abnormalities in patients with autism and suggested that these dysfunctions predate the onset of the syndrome, we performed a fine-grain characterization of the neonatal vocal and motor repertoire in reelin mutant mice to explore the developmental precursors of the disorder. Our findings evidence a general delay in motor and vocal development in heterozygous (50% reduced reelin) and reeler (lacking reelin gene) mutant mice. As a whole, an increased number of calls characterized heterozygous pup's emission. Furthermore, the typical ontogenetic peak in the number of calls characterizing wild-type pups on postnatal day 4 appeared slightly delayed in heterozygous pups (to day 6) and was quite absent in reeler littermates, which exhibited a flat profile during development. We also detected a preferential use of a specific call category (two-components) by heterozygous and reeler mice at postnatal days 6 and 8 as compared to their wild-type littermates. With regard to the analysis of spontaneous movements, a differential profile emerged early in development among the three genotypes. While only slight coordination difficulties are exhibited by heterozygous pups, all indices of motor development appear delayed in reeler mice. Overall, our results evidence a genotype-dependent deviation in ultrasonic vocal repertoire and a general delay in motor development in reelin mutant pups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.