ArticlePloS one2013
Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Converging evidence for functional connections between the lithium response and PI3K-Akt signaling.Translational psychiatry · 2024Article
- Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.Frontiers in psychiatry · 2024Article
- NaJournal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Modulation of CT1 Function: From Klotho Protein to Ammonia and Beyond.Frontiers in nutrition · 2021Article
- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
- Starvation Responses Throughout theGenetics · 2020Review
- Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.Cell reports · 2018Article
- Insulin Signaling Deficiency Produces Immobility inMolecular neuropsychiatry · 2017Article
- Food responsiveness regulates episodic behavioral states inJournal of neurophysiology · 2017Article
- Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans.Invertebrate neuroscience : IN · 2016Article
- Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
In C. elegans, pharyngeal pumping is regulated by the presence of bacteria. In response to food deprivation, the pumping rate rapidly declines by about 50-60%, but then recovers gradually to baseline levels on food after 24 hr. We used this system to study the role of insulin/IGF-1 signaling (IIS) in the recovery of pharyngeal pumping during starvation. Mutant strains with reduced function in the insulin/IGF-1 receptor, DAF-2, various insulins (INS-1 and INS-18), and molecules that regulate insulin release (UNC-64 and NCA-1; NCA-2) failed to recover normal pumping rates after food deprivation. Similarly, reduction or loss of function in downstream signaling molecules (e.g., ARR-1, AKT-1, and SGK-1) and effectors (e.g., CCA-1 and UNC-68) impaired pumping recovery. Pharmacological studies with kinase and metabolic inhibitors implicated class II/III phosphatidylinositol 3-kinases (PI3Ks) and glucose metabolism in the recovery response. Interestingly, both over- and under-activity in IIS was associated with poorer recovery kinetics. Taken together, the data suggest that optimum levels of IIS are required to maintain high levels of pharyngeal pumping during starvation. This work may ultimately provide insights into the connections between IIS, nutritional status and sarcopenia, a hallmark feature of aging in muscle.
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