ArticlePloS one2013
Parental legacy in insects: variation of transgenerational immune priming during offspring development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Is the developmental stage important for the plasticity of transgenerational immune priming?Biology open · 2026Article
- Article
- Rethinking Disease Control in Aquaculture Invertebrates: Harnessing Innate Immunity in Molluscs and Crustaceans.Pathogens (Basel, Switzerland) · 2026Review
- Transgenerational pathogen effects: Maternal pathogen exposure reduces offspring fitness.Ecology · 2025Article
- Current insights into insect immune memory.eLife · 2025Review
- Evidence for trans-generational immune priming againstFrontiers in immunology · 2025Article
- IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission.PLoS pathogens · 2024Article
- The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus inFrontiers in immunology · 2023Article
- Trans-generational immune priming against American Foulbrood does not affect the performance of honeybee colonies.Frontiers in veterinary science · 2023Article
- Molecular mechanisms of insect immune memory and pathogen transmission.PLoS pathogens · 2022Article
- Transgenerational Tolerance to Salt and Osmotic Stresses Induced by Plant Virus Infection.International journal of molecular sciences · 2022Article
- Why do insects evolve immune priming? A search for crossroads.Developmental and comparative immunology · 2022Review
- Disruption of insect immunity using analogs of the pleiotropic insect peptide hormone Neb-colloostatin: a nanotech approach for pest control II.Scientific reports · 2021Article
- Immune priming: the secret weapon of the insect world.Virulence · 2020Review
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Legacy of a Butterfly's Parental Microbiome in Offspring Performance.Applied and environmental microbiology · 2020Article
- Article
- The costs of the immune memory within generations.Die Naturwissenschaften · 2019Article
- The legacy of larval infection on immunological dynamics over metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Impairment of the immune response after transcuticular introduction of the insect gonadoinhibitory and hemocytotoxic peptide Neb-colloostatin: A nanotech approach for pest control.Scientific reports · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In insects, a parental immune challenge can prepare and enhance offspring immune activity. Previous studies of such transgenerational immune priming (TGIP) mainly focused on a single offspring life stage. However, different developmental stages may be exposed to different risks and show different susceptibility to parental immune priming. Here we addressed the question (i) whether TGIP effects on the immunity of Manduca sexta offspring vary among the different developmental offspring stages. We differentiated between unchallenged and immunochallenged offspring; for the latter type of offspring, we further investigated (ii) whether TGIP has an impact on the time that enhanced immune levels persist after offspring immune challenge. Finally, we determined (iii) whether TGIP effects on offspring performance depend on the offspring stage. Our results show that TGIP effects on phenoloxidase (PO) activity, but not on antibacterial activity, vary among unchallenged offspring stages. In contrast, TGIP effects on PO and antibacterial activity did not vary among immunochallenged offspring stages. The persistence of enhanced immune levels in immunochallenged offspring was dependent on the parental immune state. Antibacterial (but not PO) activity in offspring of immunochallenged parents decreased over five days after pupal immune challenge, whereas no significant change over time was detectable in offspring of control parents. Finally, TGIP effects on the developmental time of unchallenged offspring varied among stages; young larvae of immunochallenged parents developed faster and gained more weight than larvae of control parents. However, offspring females of immunochallenged parents laid fewer eggs than females derived from control parents. These findings suggest that the benefits which the offspring gains from TGIP during juvenile development are paid by the adults with reduced reproductive power. Our study shows that TGIP effects vary among offspring stages and depend on the type of immunity (PO or antibacterial activity) as well as the time past offspring immune challenge.
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