ArticlePloS one2013
Sex differences in age-related cardiovascular mortality.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.
- Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation.Prostaglandins, leukotrienes, and essential fatty acids · 2024Trial
- Predicting Daily Cardiovascular Emergencies Using Weather and Air Quality Data: A 23-Year Machine-Learning Analysis in Taiwan.GeoHealth · 2026Article
- Article
- Incidence and risk factors for cardiovascular mortality in Iranian adults: Findings from a 10year Yazd Healthy Heart Project Study.ARYA atherosclerosis · 2026Article
- Higher Levels of Cardiovascular Biomarkers Following Hypertensive Compared to Normotensive Pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Spatiotemporal Patterns of Non-Communicable Disease Mortality in the Metropolitan Area of the Valley of Mexico, 2000-2019.Diseases (Basel, Switzerland) · 2025Article
- Electrocardiogram abnormalities and CVD mortality: prospective cohort study of Tehran lipid and glucose study.BMC public health · 2025Article
- Spatiotemporal effects of urban micro-scale built environment on cardiovascular diseases.Scientific reports · 2025Article
- Relationship between frailty and executive function by age and sex in the Canadian Longitudinal Study on Aging.GeroScience · 2025Article
- S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease.Frontiers in physiology · 2025Review
- Interactive exploration of adverse events and multimorbidity in CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Daily social comparisons among women in midlife with elevated risk for cardiovascular disease: A within-person test of the identification/contrast model.Applied psychology. Health and well-being · 2024Article
- Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.Physiological reports · 2024Article
- Naps and cardiovascular disease risk in different age and sex groups: evidence from a large community cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Observational
- Biochemical Signals of Survival: A Study on Mortality Markers in Coronary Bypass Surgery Patients.Cureus · 2024Article
- Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure.Biomolecules · 2024Article
- The role of working conditions in educational differences in all-cause and ischemic heart disease mortality among Swedish men.Scandinavian journal of work, environment & health · 2024Article
- Predicting mortality from AI cardiac volumes mass and coronary calcium on chest computed tomography.Nature communications · 2024Article
- Gender differences in the relationship between the systemic immune-inflammation index and all-cause and cardiovascular mortality among adults with hypertension: evidence from NHANES 1999-2018.Frontiers in endocrinology · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionSex-related physiological differences result in different expressions of diseases for men and women. Data are contradicting regarding the increase in the female risk for cardiovascular disease (CVD) at mid-life. Thus, we studied possible sex differences in age-adjusted mortality for CVD and non-vascular diseases stratifying our findings by specific age groups.
methodsOver one million deaths (1 080 910) reported to the Finnish nationwide Causes of Death Register in 1986-2009 were analyzed. A total of 247 942 male deaths and 278 752 female deaths were of CVD origin, the remaining deaths were non-vascular. The annual mortality rates were calculated per 100 000 mid-year population, separately for men and women in 5-year age categories.
resultsThe age-standardized risk of death from CVD was 80% higher for men (442/100 000) than for women (246/100 000). After age 45-54 the male CVD mortality rate elevated parallel to the non-vascular mortality, whereas in women the CVD mortality elevated considerably more rapidly than the non-vascular mortality from age 60 years onwards.
conclusionsHeart disease mortality in men accelerates at a relatively young age, but in women the risk shows a steep increase at approximately 60 years of age. These data emphasize the need to identify and prevent risk factors for CVD, especially in women in their mid-life years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.