Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2013
Segmental reproducibility of retinal blood flow velocity measurements using retinal function imager.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging.Translational vision science & technology · 2022Trial
- Intraday and Interday Repeatability of Laser Speckle Contrast Imaging for Ocular Blood Flow Measurement in Healthy Subjects.Translational vision science & technology · 2026Article
- Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.Journal of clinical medicine · 2024Article
- Portable, non-invasive video imaging of retinal blood flow dynamics.Scientific reports · 2020Article
- Automated retinal microvascular velocimetry based on erythrocyte mediated angiography.Biomedical optics express · 2019Article
- The inter-visit variability of retinal blood flow velocity measurements using retinal function imager (RFI).Eye and vision (London, England) · 2018Article
- Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research.Eye and vision (London, England) · 2018Review
- The retinal function imager and clinical applications.Eye and vision (London, England) · 2018Review
- Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis.Eye and vision (London, England) · 2018Article
- The effect of sildenafil on retinal blood velocity in healthy subjects.Eye and vision (London, England) · 2018Article
- Comparison of Retinal Microvessel Blood Flow Velocities Acquired with Two Different Fields of View.Journal of ophthalmology · 2017Article
- Impaired retinal microcirculation in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2016Article
- Assessment of potential vessel segmentation pitfalls in the analysis of blood flow velocity using the Retinal Function Imager.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.Ophthalmology. GlaucomaObservational
- Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma.Journal of current glaucoma practiceReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundTo evaluate the reproducibility of blood flow velocity measurements of individual retinal blood vessel segments using retinal function imager (RFI).
methodsEighteen eyes of 15 healthy subjects were enrolled prospectively at three centers. All subjects underwent RFI imaging in two separate sessions 15 min apart by a single experienced photographer at each center. An average of five to seven serial RFI images were obtained. All images were transferred electronically to one center, and were analyzed by a single observer. Multiple blood vessel segments (each shorter than 100 μm) were co-localized on first and second session images taken at different times of the same fundus using built-in software. Velocities of corresponding segments were determined, and then the inter-session reproducibility of flow velocity was assessed by the concordance correlation co-efficient (CCC), coefficient of reproducibility (CR), and coefficient of variance (CV).
resultsInter-session CCC for flow velocity was 0.97 (95% confidence interval (CI), 0.966 to 0.9797). The CR was 1.49 mm/sec (95% CI, 1.39 to 1.59 mm/sec), and CV was 10.9%. The average arterial blood flow velocity was 3.16 mm/sec, and average venous blood flow velocity was 3.15 mm/sec. The CR for arterial and venous blood flow velocity was 1.61 mm/sec and 1.27 mm/sec respectively.
conclusionRFI provides reproducible measurements for retinal blood flow velocity for individual blood vessel segments, with 10.9% variability.
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