ArticleNeuroscience bulletin2013
Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat.
Article in Neuroscience bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- TGF-β1 Improves Nerve Regeneration and Functional Recovery After Sciatic Nerve Injury by Alleviating Inflammation.Biomedicines · 2025Article
- Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2-STAT3 pathway.Journal of molecular histology · 2025Article
- Fas ligand regulate nerve injury and repair by affecting AKT, β-catenin, and NF-κB pathways.IBRO neuroscience reports · 2024Article
- Baculoviral inhibitor of apoptosis protein repeat-containing protein 3 delays early Wallerian degeneration after sciatic nerve injury.Neural regeneration research · 2022Article
- Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.Neural regeneration research · 2022Article
- Article
- Sexual Dimorphism of Early Transcriptional Reprogramming in Dorsal Root Ganglia After Peripheral Nerve Injury.Frontiers in molecular neuroscience · 2021Article
- Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve.Neural regeneration research · 2019Article
- Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration.Neural regeneration research · 2019Article
- Systemic functional enrichment and ceRNA network identification following peripheral nerve injury.Molecular brain · 2018Article
- Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro.Scientific reports · 2018Article
- Spatiotemporal microRNA profile in peripheral nerve regeneration: miR-138 targets vimentin and inhibits Schwann cell migration and proliferation.Neural regeneration research · 2018Article
- Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury.Frontiers in molecular neuroscience · 2018Article
- Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury.Neural regeneration research · 2017Article
- Analysis of temporal expression profiles after sciatic nerve injury by bioinformatic method.Scientific reports · 2017Article
- Critical signaling pathways during Wallerian degeneration of peripheral nerve.Neural regeneration research · 2017Article
- Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury.BMC neuroscience · 2017Article
- Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.International journal of molecular sciences · 2017Article
- Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves.Frontiers in cellular neuroscience · 2017Article
- Identification of Changes in Gene expression of rats after Sensory and Motor Nerves Injury.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wallerian degeneration (WD) remains an important research topic. Many genes are differentially expressed during the process of WD, but the precise mechanisms responsible for these differentiations are not completely understood. In this study, we used microarrays to analyze the expression changes of the distal nerve stump at 0, 1, 4, 7, 14, 21 and 28 days after sciatic nerve injury in rats. The data revealed 6 076 differentially-expressed genes, with 23 types of expression, specifically enriched in genes associated with nerve development and axonogenesis, cytokine biosynthesis, cell differentiation, cytokine/chemokine production, neuron differentiation, cytokinesis, phosphorylation and axon regeneration. Kyoto Encyclopedia of Genes and Genomes pathway analysis gave findings related mainly to the MAPK signaling pathway, the Jak-STAT signaling pathway, the cell cycle, cytokine-cytokine receptor interaction, the p53 signaling pathway and the Wnt signaling pathway. Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative PCR, Western blot, and immunohistochemistry. Our findings contribute to a better understanding of the functional analysis of differentially-expressed genes in WD and may shed light on the molecular mechanisms of nerve degeneration and regeneration.
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