ReviewReviews in endocrine & metabolic disorders2013
Insulin resistance, lipodystrophy and cardiometabolic syndrome in HIV/AIDS.
Review in Reviews in endocrine & metabolic disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2015Trial
- Intestinal Microbiome, Fecal Fermentation Profile, and Health Indices in HIV-Positive Men Versus Normal Controls Without HIV.Nutrients · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China.AIDS (London, England) · 2025Article
- Forecasting and validating fat mass ratio models through anthropometric measurements and health-related factors among people with HIV: a cross-sectional investigation.Annals of translational medicine · 2024Article
- HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps.Circulation research · 2024Review
- Patients living with HIV have quantitatively inadequate food consumption.Archives of endocrinology and metabolism · 2023Article
- Unpacking determinants and consequences of food insecurity for insulin resistance among people living with HIV: Conceptual framework and protocol for the NOURISH-OK study.Frontiers in clinical diabetes and healthcare · 2022Article
- Systems Analysis of Gut Microbiome Influence on Metabolic Disease in HIV-Positive and High-Risk Populations.mSystems · 2021Article
- Cerebral Vascular Toxicity of Antiretroviral Therapy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Review
- Cachexia, a Systemic Disease beyond Muscle Atrophy.International journal of molecular sciences · 2020Review
- Plasma acylcarnitines and progression of carotid artery atherosclerosis in HIV infection.AIDS (London, England) · 2019Article
- Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.Diabetes & vascular disease research · 2018Article
- Cardiovascular Disease in the Setting of Human Immunodeficiency Virus Infection.Current cardiology reviews · 2018Review
- Hemeoxygenase-1 as a Novel Driver in Ritonavir-Induced Insulin Resistance in HIV-1-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Vitamin D Supplementation Does Not Affect Metabolic Changes Seen With ART Initiation.Open forum infectious diseases · 2017Article
- Harveian Oration 2016: Some observations on the causes and consequences of obesity.Clinical medicine (London, England) · 2016Article
- International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK.Journal of the International AIDS Society · 2016Article
- Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz.Molecular pharmacology · 2015Article
- Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals.Journal of neuroinflammation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV associated insulin resistance, lipodistrophy and cardiometabolic syndrome have been extensively studied and continue to be the scope of much research. There is compelling evidence that both the HIV itself and the therapeutical regimes are major contributors to all of these associated comorbidities. HIV has increasingly been recognized as a disease of accelerated aging, manifested by increased progression of vascular disease and cellular markers of aging. The antiretroviral medication can increase insulin resistance and cause lipotoxocity and HIV-associated lipodystrophy leading to cardiovascular pathology. In this article we review the pathogenesis, management, and prevention of the long-term complications of HIV and its therapies, including cardiovascular disease, lipodystrophy, and insulin resistance along with the growing focus on biomarkers to predict development of end-organ disease. Through a focused literature search we review the established evidence, the developing research about the treatment strategies in treated HIV infection as well as identify potential areas for future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.