ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Neuronal mechanisms of respiratory pattern generation are evolutionary conserved.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Detection of central and obstructive sleep apneas in mice: A new surgical and recording protocol.PloS one · 2025Article
- Structure and Topography of Facial Branchiomotor Neuron Dendrites in Larval Zebrafish (Danio rerio).The Journal of comparative neurology · 2024Article
- Early development of respiratory motor circuits in larval zebrafish (Danio rerio).The Journal of comparative neurology · 2023Article
- Review
- Revisiting the two rhythm generators for respiration in lampreys.Frontiers in neuroanatomy · 2023Article
- Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish.eLife · 2021Article
- Molecular characterization of frog vocal neurons using constellation pharmacology.Journal of neurophysiology · 2020Article
- Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Inspiring song: The role of respiratory circuitry in the evolution of vertebrate vocal behavior.Developmental neurobiology · 2020Review
- Genomic discovery of ion channel genes in the central nervous system of the lamprey Petromyzon marinus.Marine genomics · 2019Article
- Oviposition-like central pattern generators in pregenital segments of male and female grasshoppers.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey.The Journal of physiology · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Evolution of lung breathing from a lungless primitive vertebrate.Respiratory physiology & neurobiology · 2016Article
- Neurotoxicity of prenatal alcohol exposure on medullary pre-Bötzinger complex neurons in neonatal rats.Neural regeneration research · 2015Article
- Blockade of neurokinin-1 receptors in the ventral respiratory column does not affect breathing but alters neurochemical release.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.PloS one · 2015Article
- Mechanisms of coordination in distributed neural circuits: encoding coordinating information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- GABAergic and glycinergic inputs modulate rhythmogenic mechanisms in the lamprey respiratory network.The Journal of physiology · 2014Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A brainstem region, the paratrigeminal respiratory group (pTRG), has been suggested to play a crucial role in the respiratory rhythm generation in lampreys. However, a detailed characterization of the pTRG region is lacking. The present study performed on isolated brainstem preparations of adult lampreys provides a more precise localization of the pTRG region with regard to both connectivity and neurochemical markers. pTRG neurons projecting to the vagal motoneuronal pool were identified in a restricted area of the rostral rhombencephalon at the level of the isthmic Müller cell I1 close to sulcus limitans of His. Unilateral microinjections of lidocaine, muscimol, or glutamate antagonists into the pTRG inhibited completely the bilateral respiratory activity. In contrast, microinjections of glutamate agonists enhanced the respiratory activity, suggesting that this region is critical for the respiratory pattern generation. The retrogradely labeled pTRG neurons are glutamatergic and surrounded by terminals with intense substance P immunoreactivity. Cholinergic neurons were seen close to, and intermingled with, pTRG neurons. In addition, α-bungarotoxin binding sites (indicating nicotinic receptors) were found throughout the pTRG area and particularly on the soma of these neurons. During apnea, induced by blockade of ionotropic glutamate receptors within the same region, microinjections of 1 μm substance P or 1 mm nicotine into the pTRG restored rhythmic respiratory activity. The results emphasize the close similarities between the pTRG and the mammalian pre-Bötzinger complex as a crucial site for respiratory rhythmogenesis. We conclude that some basic features of the excitatory neurons proposed to generate respiratory rhythms are conserved throughout evolution.
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