Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Pooled it
- Frequency-Dependent Whole-Brain Reconfiguration Following Left DLPFC rTMS in Older Adults: A 106-Channel fNIRS Study.Sensors (Basel, Switzerland) · 2026Trial
- Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition.Scientific reports · 2021Trial
- Cerebellar transcranial alternating current stimulation in the gamma range applied during the acquisition of a novel motor skill.Scientific reports · 2020Trial
- The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.Experimental brain research · 2018Trial
- tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older Adults.Neural plasticity · 2017Trial
- Stimulation selectivity in transcranial motor evoked potentials for monitoring during surgery for supratentorial lesions.Clinical neurophysiology practice · 2026Article
- Cerebellar Brain Inhibition and Its Association with Motor Inhibition and Reaction Time In Younger and Older Adults.Cerebellum (London, England) · 2025Article
- Differences in motor learning-related structural plasticity of layer 2/3 parvalbumin-positive interneurons of the young and aged motor cortex.GeroScience · 2025Article
- Changes in the Brain with an External Focus of Attention: Neural Correlates.Exercise and sport sciences reviews · 2025Review
- Native learning ability and not age determines the effects of brain stimulation.NPJ science of learning · 2024Article
- GABA, Aging and Exercise: Functional and Intervention Considerations.Neuroscience insights · 2024Review
- Neurofeedback-induced desynchronization of sensorimotor rhythm elicits pre-movement downregulation of intracortical inhibition that shortens simple reaction time in humans: A double-blind, sham-controlled randomized study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly.Brain sciences · 2023Article
- Directed functional connectivity of the sensorimotor system in young and older individuals.Frontiers in aging neuroscience · 2023Article
- Differences in motor inhibition in young and older musicians and non-musicians at rest.Frontiers in aging neuroscience · 2023Article
- Considerable effects of lateralization and aging in intracortical excitation and inhibition.Frontiers in neuroscience · 2023Article
- Compensatory cognition in neurological diseases and aging: A review of animal and human studies.Aging brain · 2023Review
- Dissecting motor skill acquisition: Spatial coordinates take precedence.Science advances · 2022Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes throughout the lifespan from development to aging, here, the aging motor system was used as a model to analyze the interdependence of plastic alterations within the inhibitory motorcortical network and level of behavioral performance. Double-pulse transcranial magnetic stimulation (dpTMS) was used to examine inhibition by means of short-interval intracortical inhibition (SICI) of the contralateral primary motor cortex in a sample of 64 healthy right-handed human subjects covering a wide range of the adult lifespan (age range 20-88 years, mean 47.6 ± 20.7, 34 female). SICI was evaluated during resting state and in an event-related condition during movement preparation in a visually triggered simple reaction time task. In a subgroup (N = 23), manual motor performance was tested with tasks of graded dexterous demand. Weak resting-state inhibition was associated with an overall lower manual motor performance. Better event-related modulation of inhibition correlated with better performance in more demanding tasks, in which fast alternating activation of cortical representations are necessary. Declining resting-state inhibition was associated with weakened event-related modulation of inhibition. Therefore, reduced resting-state inhibition might lead to a subsequent loss of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission; the consequence is an inevitable decline in motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.