Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Reduced serotonin transporter availability decreases prefrontal control of the amygdala.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals.PLoS biology · 2017Trial
- Normalizing effect of heroin maintenance treatment on stress-induced brain connectivity.Brain : a journal of neurology · 2015Trial
- Enhancing resilience, flexibility, and well-being through cognitive-emotional training: behavioral and neural evidence.Scientific reports · 2026Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- Inhibitory Systems in Brain Evolution: Pathways of Vulnerability in Neurodevelopmental Disorders.Brain, behavior and evolution · 2025Review
- Article
- Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex.Nature communications · 2023Article
- Anterior prefrontal brain activity during emotion control predicts resilience to post-traumatic stress symptoms.Nature human behaviour · 2021Article
- The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration.Addiction biology · 2021Article
- Effects of stress on functional connectivity during verbal processing.Brain imaging and behavior · 2020Article
- Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling.eLife · 2020Article
- Human Lateral Frontal Pole Contributes to Control over Emotional Approach-Avoidance Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Threat-Avoidance Tendencies Moderate the Link Between Serotonin Transporter Genetic Variation and Reactive Aggression.Frontiers in behavioral neuroscience · 2020Article
- Structural equation modeling of the associations between amygdala activation, personality, and internalizing, externalizing symptoms of psychopathology.Personality neuroscience · 2020Article
- Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys.eLife · 2019Article
- Understanding psychiatric disorder by capturing ecologically relevant features of learning and decision-making.Behavioural brain research · 2018Review
- Cortical Oscillatory Mechanisms Supporting the Control of Human Social-Emotional Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Influence of Serotonin Transporter SLC6A4 Genotype on the Effect of Psychosocial Stress on Cognitive Performance: An Exploratory Pilot Study.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2018Article
- Neural correlates of emotional action control in anger-prone women with borderline personality disorder.Journal of psychiatry & neuroscience : JPN · 2018Article
- Associations between genetic risk, functional brain network organization and neuroticism.Brain imaging and behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers of the serotonin transporter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or by reduced prefrontal regulation. This study distinguishes between these two hypotheses by using dynamic causal modeling of fMRI data acquired in a preselected cohort of human s-carriers and homozygous long-allele carriers. Increased amygdala activity in s-carriers originates from reduced prefrontal inhibitory regulation when social emotional behavior needs to be controlled, suggesting a mechanism for increased vulnerability to psychopathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.