ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention.Diabetes care · 2016Trial
- Circadian disruption as a driver and target in neurodegenerative diseases: from molecular mechanisms to chronotherapeutic strategies.Metabolic brain disease · 2026Review
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer.Molecular psychiatry · 2025Article
- Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction.Nature metabolism · 2025Article
- Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection.Animal models and experimental medicine · 2025Review
- Comprehensive Bioinformatics Analysis Reveals Molecular Signatures and Potential Caloric Restriction Mimetics with Neuroprotective Effects: Validation in an In Vitro Stroke Model.Journal of molecular neuroscience : MN · 2025Article
- The Role of Calorie Restriction in Modifying the Ageing Process through the Regulation of SIRT1 Expression.Sub-cellular biochemistry · 2024Review
- The Study of Overexpression of Peroxiredoxin-2 Reduces MPPNeurochemical research · 2023Article
- The roles of sirtuins in ferroptosis.Frontiers in physiology · 2023Review
- Shedding light on structure, function and regulation of human sirtuins: a comprehensive review.3 Biotech · 2023Review
- SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders.Aging clinical and experimental research · 2022Review
- Dietary regulation in health and disease.Signal transduction and targeted therapy · 2022Review
- Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice.Genetics · 2022Article
- Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.Frontiers in immunology · 2022Review
- Ketogenic Diet as a potential treatment for traumatic brain injury in mice.Scientific reports · 2021Article
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Article
- Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?Life (Basel, Switzerland) · 2021Review
- miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy.Experimental and therapeutic medicine · 2021Article
11 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Caloric restriction (CR) is a dietary regimen known to promote lifespan by slowing down the occurrence of age-dependent diseases. The greatest risk factor for neurodegeneration in the brain is age, from which follows that CR might also attenuate the progressive loss of neurons that is often associated with impaired cognitive capacities. In this study, we used a transgenic mouse model that allows for a temporally and spatially controlled onset of neurodegeneration to test the potentially beneficial effects of CR. We found that in this model, CR significantly delayed the onset of neurodegeneration and synaptic loss and dysfunction, and thereby preserved cognitive capacities. Mechanistically, CR induced the expression of the known lifespan-regulating protein SIRT1, prompting us to test whether a pharmacological activation of SIRT1 might recapitulate CR. We found that oral administration of a SIRT1-activating compound essentially replicated the beneficial effects of CR. Thus, SIRT1-activating compounds might provide a pharmacological alternative to the regimen of CR against neurodegeneration and its associated ailments.
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