ArticleJournal of neurophysiology2013
The roles of monkey M1 neuron classes in movement preparation and execution.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Resting fMRI functional connectivity reflects fluctuations in inhibitory interneuron activity.bioRxiv : the preprint server for biology · 2026Article
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- Mapping neural subspace dynamics onto the structure of the mouse descending motor system.bioRxiv : the preprint server for biology · 2025Article
- Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.Communications biology · 2025Article
- 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking.bioRxiv : the preprint server for biology · 2025Article
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- Dynamic control of sequential retrieval speed in networks with heterogeneous learning rules.eLife · 2024Article
- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortico-cortical drive in a coupled premotor-primary motor cortex dynamical system.Cell reports · 2022Article
- Motor cortical influence relies on task-specific activity covariation.Cell reports · 2022Article
- Grasp-squeeze adaptation to changes in object compliance leads to dynamic beta-band communication between primary somatosensory and motor cortices.Scientific reports · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
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- Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat.Frontiers in aging neuroscience · 2022Article
- Statistical neuroscience in the single trial limit.Current opinion in neurobiology · 2021Review
- Article
- Local and system mechanisms for action execution and observation in parietal and premotor cortices.Current biology : CB · 2021Article
- Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface.Nature communications · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The motor cortices exhibit substantial activity while preparing movements, yet the arm remains still during preparation. We investigated whether a subpopulation of presumed inhibitory neurons in primary motor cortex (M1) might be involved in "gating" motor output during preparation, while permitting output during movement. This hypothesis predicts a release of inhibition just before movement onset. In data from M1 of two monkeys, we did not find evidence for this hypothesis: few neurons exhibited a clear pause during movement, and these were at the tail end of a broad distribution. We then identified a subpopulation likely to be enriched for inhibitory interneurons, using their waveform shapes. We found that the firing rates of this subpopulation tended to increase during movement instead of decreasing as predicted by the M1 gating model. No clear subset that might implement an inhibitory gate was observed. Together with previous evidence against upstream inhibitory mechanisms in premotor cortex, this provides evidence against an inhibitory "gate" for motor output in cortex. Instead, it appears that some other mechanism must likely exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.