ArticleJournal of neurophysiology2013
Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Regulation of amygdala and dopamine system in naïve and chronic alcohol states.Alcohol (Fayetteville, N.Y.) · 2026Article
- Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze.The European journal of neuroscience · 2025Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- Computational modeling of fear and stress responses: validation using consolidated fear and stress protocols.Frontiers in systems neuroscience · 2024Article
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Prefrontal modulation of anxiety through a lens of noradrenergic signaling.Frontiers in systems neuroscience · 2023Review
- Structure and function differences in the prelimbic cortex to basolateral amygdala circuit mediate trait vulnerability in a novel model of acute social defeat stress in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Hippocampal Inputs in the Prelimbic Cortex Curb Fear after Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prefrontal cortical and nucleus accumbens contributions to discriminative conditioned suppression of reward-seeking.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Memory Prosthesis: Is It Time for a Deep Neuromimetic Computing Approach?Frontiers in neuroscience · 2019Article
- Prefrontal circuits signaling active avoidance retrieval and extinction.Psychopharmacology · 2019Article
- Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex.eLife · 2018Article
- Interplay of prefrontal cortex and amygdala during extinction of drug seeking.Brain structure & function · 2018Article
- Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala.BMC biology · 2017Article
- Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.Nature neuroscience · 2017Article
- Article
- Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model.PLoS computational biology · 2016Article
- Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
The acquisition and expression of conditioned fear depends on prefrontal-amygdala circuits. Auditory fear conditioning increases the tone responses of lateral amygdala neurons, but the increase is transient, lasting only a few hundred milliseconds after tone onset. It was recently reported that that the prelimbic (PL) prefrontal cortex transforms transient lateral amygdala input into a sustained PL output, which could drive fear responses via projections to the lateral division of basal amygdala (BL). To explore the possible mechanisms involved in this transformation, we developed a large-scale biophysical model of the BL-PL network, consisting of 850 conductance-based Hodgkin-Huxley-type cells, calcium-based learning, and neuromodulator effects. The model predicts that sustained firing in PL can be derived from BL-induced release of dopamine and norepinephrine that is maintained by PL-BL interconnections. These predictions were confirmed with physiological recordings from PL neurons during fear conditioning with the selective β-blocker propranolol and by inactivation of BL with muscimol. Our model suggests that PL has a higher bandwidth than BL, due to PL's decreased internal inhibition and lower spiking thresholds. It also suggests that variations in specific microcircuits in the PL-BL interconnection can have a significant impact on the expression of fear, possibly explaining individual variability in fear responses. The human homolog of PL could thus be an effective target for anxiety disorders.
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Registered trials
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