Melancholic and atypical subtypes of depression represent distinct pathophysiological entities: CRH, neural circuits, and the diathesis for anxiety and depression.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Dietary patterns and the risk of depression in adults: a systematic review of observational studies.European journal of nutrition · 2014
   Pooled it
2. Changes in Multiple microRNA Levels with Antidepressant Treatment Are Associated with Remission and Interact with Key Pathways: A Comprehensive microRNA Analysis.International journal of molecular sciences · 2023
   Trial
3. The effects of ketamine on typical and atypical depressive symptoms.Acta psychiatrica Scandinavica · 2020
   Trial
4. Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder.Cognitive, affective & behavioral neuroscience · 2016
   Trial
5. Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body.The Journal of clinical endocrinology and metabolism · 2015
   Trial
6. Mineralocorticoid receptor stimulation improves cognitive function and decreases cortisol secretion in depressed patients and healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
   Trial
7. Childhood depression subscales using repeated sessions on Children's Depression Rating Scale - revised (CDRS-R) scores.Journal of child and adolescent psychopharmacology · 2014
   Trial
8. Brain Structures, Circuits, and Networks Involved in Immune Regulation, Periodontal Health, and Disease.Life (Basel, Switzerland) · 2025
   Review
9. Neuroanatomical and Functional Correlates in Depressive Spectrum: A Narrative Review.Journal of personalized medicine · 2025
   Review
10. Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease.Periodontology 2000 · 2024
    Review
11. Elucidating the Possible Role of FoxO in Depression.Neurochemical research · 2021
    Review
12. Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene.Translational psychiatry · 2021
    Article
13. Fatigue in Cancer and Neuroinflammatory and Autoimmune Disease: CNS Arousal Matters.Brain sciences · 2020
    Article
14. Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states.Molecular psychiatry · 2020
    Article
15. Comparison of short-term (saliva) and long-term (hair) cortisol levels in out-patients with melancholic and non-melancholic major depression.BJPsych open · 2020
    Article
16. Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.Journal of affective disorders · 2018
    Article
17. The cortisol:C-reactive protein ratio and negative affect reactivity in depressed adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017
    Article
18. The role of adipokines in the rapid antidepressant effects of ketamine.Molecular psychiatry · 2017
    Article
19. Polygenic dissection of major depression clinical heterogeneity.Molecular psychiatry · 2016
    Article
20. IL-1β and BDNF are associated with improvement in hypersomnia but not insomnia following exercise in major depressive disorder.Translational psychiatry · 2015
    Review

Corrections and comments

• Comment on
  Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression.2013
• Comment on
  CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression.2013

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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