ArticleJournal of virology2013
Structure and functional analysis of the host recognition device of lactococcal phage tuc2009.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Cryo-EM structure of bacteriophage Nocturne116: insights into the architecture of c2-likeJournal of virology · 2026Article
- Phage Adsorption to Gram-Positive Bacteria.Viruses · 2023Review
- Exploring Structural Diversity among Adhesion Devices Encoded by Lactococcal P335 Phages with AlphaFold2.Microorganisms · 2022Article
- Article
- Bacteriophage-host interactions as a platform to establish the role of phages in modulating the microbial composition of fermented foods.Microbiome research reports · 2022Review
- Reprogramming bacteriophage host range: design principles and strategies for engineering receptor binding proteins.Current opinion in biotechnology · 2021Review
- Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages.Microbial biotechnology · 2020Article
- Conserved and Diverse Traits of Adhesion Devices fromViruses · 2020Review
- A Specific Sugar Moiety in the Lactococcus lactis Cell Wall Pellicle Is Required for Infection by CHPC971, a Member of the Rare 1706 Phage Species.Applied and environmental microbiology · 2019Article
- Article
- A comparative genomics approach for identifying host-range determinants in Streptococcus thermophilus bacteriophages.Scientific reports · 2019Article
- Isolation and Characterization ofViruses · 2019Article
- Cell Wall Glycans Mediate Recognition of the Dairy Bacterium Streptococcus thermophilus by Bacteriophages.Applied and environmental microbiology · 2018Article
- Identification of Dual Receptor Binding Protein Systems in Lactococcal 936 Group Phages.Viruses · 2018Article
- Review
- Genetic and functional characterisation of the lactococcal P335 phage-host interactions.BMC genomics · 2017Article
- Biocidal Inactivation ofFrontiers in microbiology · 2017Article
- Global Survey and Genome Exploration of Bacteriophages Infecting the Lactic Acid BacteriumFrontiers in microbiology · 2017Article
- F-Type Bacteriocins of Listeria monocytogenes: a New Class of Phage Tail-Like Structures Reveals Broad Parallel Coevolution between Tailed Bacteriophages and High-Molecular-Weight Bacteriocins.Journal of bacteriology · 2016Article
- The Presence of Two Receptor-Binding Proteins Contributes to the Wide Host Range of Staphylococcal Twort-Like Phages.Applied and environmental microbiology · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many phages employ a large heteropolymeric organelle located at the tip of the tail, termed the baseplate, for host recognition. Contrast electron microscopy (EM) of the lactococcal phage Tuc2009 baseplate and its host-binding subunits, the so-called tripods, allowed us to obtain a low-resolution structural image of this organelle. Structural comparisons between the baseplate of the related phage TP901-1 and that of Tuc2009 demonstrated that they are highly similar, except for the presence of an additional protein in the Tuc2009 baseplate (BppATuc2009), which is attached to the top of the Tuc2009 tripod structure. Recombinantly produced Tuc2009 or TP901-1 tripods were shown to bind specifically to their particular host cell surfaces and are capable of almost fully and specifically eliminating Tuc2009 or TP901-1 phage adsorption, respectively. In the case of Tuc2009, such adsorption-blocking ability was reduced in tripods that lacked BppATuc2009, indicating that this protein increases the binding specificity and/or affinity of the Tuc2009 tripod to its host receptor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.