Evidence map›Paper›PMID 23698299›Full record

ArticleJournal of virology2013

Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.

Peter H Goff, Florian Krammer, Rong Hai, Christopher W Seibert, Irina Margine, Adolfo García-Sastre, Peter Palese

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Peter H GoffDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Florian Krammer
Rong Hai
Christopher W Seibert
Irina Margine
Adolfo García-Sastre
Peter Palese
Icahn School of Medicine at Mount Sinai · US

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PALESE, PETER · 2012 to 2022
$17.6M
NIAID NIH HHS 1P01AI097092-01A1NIAID NIH HHS P01 AI097092NIAID NIH HHS U54 AI057158NIAID NIH HHS U54 AI057158-06PHS HHS HHSN26620070010C
6 · The paper itself

Abstract

Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.

Indexed as

AnimalsAntibodies, ViralBlotting, WesternChinaCluster AnalysisCommunicable Diseases, EmergingConserved SequenceCross ReactionsEnzyme-Linked Immunosorbent AssayGenetic VectorsHemagglutinin Glycoproteins, Influenza VirusHumansImmune SeraInfluenza A virusMiceModels, GeneticAntibodies, Viralhemagglutinin, avian influenza A virusHemagglutinin Glycoproteins, Influenza VirusImmune SeraViral Vaccines

Identifiers

PMID23698299
PMCPMC3700175
OpenAlexW2120882015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.