ArticleMolecules (Basel, Switzerland)2013
Chemical constituents from the rhizomes of Smilax glabra and their antimicrobial activity.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 131 citations in OpenAlex.
- Article
- Network Pharmacology, Molecular Docking and Dynamics Simulation Reveal the Anti-Colitis Mechanism ofClinical and experimental gastroenterology · 2026Article
- In Vitro Biological Activities and Phytochemical Analyses ofMolecules (Basel, Switzerland) · 2025Article
- Bioactives derived from Brazilian native flora with antimicrobial and anticancer activity.BMC complementary medicine and therapies · 2025Article
- Comprehensive characterisation of the active ingredients ofFrontiers in pharmacology · 2025Article
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- Comparison of Neurogenesis Promotion Effects between Cinnamoylquinic Acids in Neural Stem Cells from Adult Mice Brains.ACS chemical neuroscience · 2024Article
- Advances in the chemical constituents, pharmacological activity, and clinical application ofHeliyon · 2024Review
- HPLC-HESI-MS/MS Analysis of Phenolic Compounds fromPlants (Basel, Switzerland) · 2024Article
- Article
- Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem.Phytochemistry · 2023Article
- Anti-Adipogenic Activity of Secondary Metabolites Isolated fromInternational journal of molecular sciences · 2023Article
- Preparation and characterization of zein-lecithin-total flavonoids fromFood chemistry: X · 2023Article
- A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.Integrative medicine (Encinitas, Calif.) · 2023Review
- Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity.Microorganisms · 2023Article
- Influence of heat processing on the anti-inflammatory activity of freshFood chemistry: X · 2022Article
- Tentative Identification of Phytochemicals fromPlants (Basel, Switzerland) · 2022Article
- Review
- A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis.American journal of cancer research · 2022Article
- Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2.Signal transduction and targeted therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Six new phenolic compounds, named smiglabrone A (1), smiglabrone B (2), smilachromanone (3), smiglastilbene (4), smiglactone (5), smiglabrol (6), together with fifty-seven known ones 7-63 were isolated from the rhizomes of Smilax glabra. Their structures were elucidated on the basis of extensive spectroscopic analyses, as well as by comparison with literature data. Twenty-seven of these compounds were obtained from and identified in the genus Smilax for the first time. The absolute configuration of (2S)-1,2-O-di-trans-p-coumaroylglycerol (43) was determined for the first time using the exciton-coupled circular dichroism (ECCD) method. Thirty isolated compounds were evaluated for their antimicrobial activity against three Gram-negative bacteria, three Gram-positive bacteria and one fungus, and the corresponding structure-activity relationships were also discussed. Eighteen compounds were found to be antimicrobial against the microorganisms tested and the minimum inhibitory concentrations (MIC) were in the range of 0.0794-3.09 mM. Among them, compound 1 showed antimicrobial activity against Canidia albicans with MIC value of 0.146 mM, which was stronger than cinchonain Ia with an MIC of 0.332 mM. Compounds 3 and 4 exhibited inhibitory activity against Staphylococcus aureus with MIC values of 0.303 and 0.205 mM, respectively. The results indicated that these antimicrobial constituents of this crude drug might be responsible for its clinical antimicrobial effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.