ArticleProceedings. Biological sciences2013
Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed.
- A Research Project for Secondary Schools on Urban Plant Ecological Genetics.Ecology and evolution · 2026Article
- Engineering Wheat for Compound Climate Extremes: Molecular Trade-Offs, Stress Memory, and Precision Genome Editing for Yield-Stable Resilience.Plants (Basel, Switzerland) · 2026Review
- Differentiation for drought strategy but conserved plasticity to heat and drought in locally adapted populations of Arabidopsis thaliana.Annals of botany · 2026Article
- Morphological, Physiological and Transcriptomic Changes in Response to Water Deficit Stress inInternational journal of molecular sciences · 2026Article
- Adaptation to seasonal drought in Arabis alpina is linked to the demographic history and climatic changes since the last glacial maximum.Molecular biology and evolution · 2026Article
- In Situ GWAS in Two Range-Edge Populations of European Beech (Fagus sylvatica L.) Identify Genetic Factors of Adaptation to Climate Change.Molecular ecology · 2026Article
- MYB59 is Linked to Natural Variation of Water-Use Associated With Warmer Temperatures inPlant-environment interactions (Hoboken, N.J.) · 2026Article
- Differentiation for drought strategy but conserved plasticity to heat and drought in locally adapted populations ofbioRxiv : the preprint server for biology · 2026Article
- Experimental Validation of Genome-Environment Associations in Arabidopsis.Molecular ecology · 2025Article
- Delay in Flowering Time inInternational journal of molecular sciences · 2025Article
- Unique genetic bases of repeated life-history divergence associated with high altitude adaptation inbioRxiv : the preprint server for biology · 2025Article
- Genomic signatures of adaptation in seed traits in the wild plant Brassica incana.Communications biology · 2025Article
- Transcriptional regulation of SlFRIGIDA-like improve antioxidant system in tomato under cold.BMC plant biology · 2025Article
- Species-wide gene editing of a flowering regulator reveals hidden phenotypic variation.PLoS biology · 2025Article
- The genomics and physiology of abiotic stressors associated with global elevational gradients in Arabidopsis thaliana.The New phytologist · 2024Article
- Climate biogeography ofJournal of biogeography · 2024Article
- Dynamic QTL mapping revealed primarily the genetic structure of photosynthetic traits in castor (Ricinus communis L.).Scientific reports · 2023Article
- Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.PLoS biology · 2023Article
- Genomic Basis of Adaptation to a Novel Precipitation Regime.Molecular biology and evolution · 2023Article
- Gene-by-environment interactions in plants: Molecular mechanisms, environmental drivers, and adaptive plasticity.The Plant cell · 2023Review
1 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation. In the simplest case, unlinked loci and uncorrelated phenotypes respond directly to multivariate selection and permit unrestricted paths to adaptive peaks. By contrast, 'antagonistic' pleiotropic loci may constrain adaptation by affecting variation of many traits and limiting the direction of trait correlations to vectors that are not favoured by selection. However, certain pleiotropic configurations may improve the conditions for adaptive evolution. Here, we present evidence that the Arabidopsis thaliana gene FRI (FRIGIDA) exhibits 'adaptive' pleiotropy, producing trait correlations along an axis that results in two adaptive strategies. Derived, low expression FRI alleles confer a 'drought escape' strategy owing to fast growth, low water use efficiency and early flowering. By contrast, a dehydration avoidance strategy is conferred by the ancestral phenotype of late flowering, slow growth and efficient water use during photosynthesis. The dehydration avoidant phenotype was recovered when genotypes with null FRI alleles were transformed with functional alleles. Our findings indicate that the well-documented effects of FRI on phenology result from differences in physiology, not only a simple developmental switch.
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