ArticleNucleus (Austin, Tex.)
Nuclear mechanics: lamin webs and pathological blebs.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms.Epigenetics & chromatin · 2022Article
- A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.Investigative ophthalmology & visual science · 2015Article
- Polymer models of interphase chromosomes.Nucleus (Austin, Tex.)Review
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Abstract
Anomalies in the three-dimensional shape of the nucleus are associated with a number of genetic diseases. These shape distortions include lobulated structures, with localized bulges referred to as nuclear blebs. Blebbing can result from mutations in genes encoding lamin intermediate filaments that form the lamin cortex, a thin meshwork lining the nuclear envelope. However, the biophysical origins of nuclear blebs remain a mystery. A recent study by Funkhouser et al. provides a theoretical model in which the lamin cortex is modeled as a thin, inhomogeneous elastic shell. This model shows that partial segregation of different lamin sub-networks-each with distinct mechanical properties-can lead to shell morphologies similar to blebbed nuclei in living cells.
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