ArticleMarine drugs2013
Extract from the zooxanthellate jellyfish Cotylorhiza tuberculata modulates gap junction intercellular communication in human cell cultures.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Marine Biotoxins as Potential Nematocide: Impact of Cassiopea andromeda Venom Against Acute and Chronic Trichinellosis in Murine model.Acta parasitologica · 2026Article
- Chemical Defenses in Medusozoa.Marine drugs · 2025Review
- Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025Article
- Article
- Wild or Reared?Marine drugs · 2025Article
- Characterization and phylogenetic analysis of the complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2024Article
- The Effect of the Persian Gulf Jellyfish (Cassiopea andromeda) Venom on the Expression of P15, P21, P53, DNMT1, and Bcl-2 in Acute Lymphoblastic Leukemia Jurkat Cells.International journal of hematology-oncology and stem cell research · 2023Article
- The Zooxanthellate Jellyfish HolobiontMarine drugs · 2023Article
- Jellyfishes-Significant Marine Resources with Potential in the Wound-Healing Process: A Review.Marine drugs · 2023Review
- Chemical Compositions and Experimental and Computational Modeling of the Anticancer Effects of Cnidocyte Venoms of JellyfishMarine drugs · 2023Article
- Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds.Marine drugs · 2022Article
- Tyrosinase Inhibitory and Antioxidant Activity of Enzymatic Protein Hydrolysate from Jellyfish (Foods (Basel, Switzerland) · 2022Article
- Jellyfish Bioprospecting in the Mediterranean Sea: Antioxidant and Lysozyme-Like Activities fromMarine drugs · 2021Article
- Biochemical Characterization ofMarine drugs · 2021Article
- Nomad JellyfishMolecules (Basel, Switzerland) · 2021Article
- Antioxidant and Pro-Oxidant Capacities as Mechanisms of Photoprotection of Olive Polyphenols on UVA-Damaged Human Keratinocytes.Molecules (Basel, Switzerland) · 2021Article
- The Microbial Community Associated withMarine drugs · 2020Article
- Identification of Safety and Quality Parameters for Preparation of Jellyfish Based Novel Food Products.Foods (Basel, Switzerland) · 2019Article
- Pro-Apoptotic Effect of Grape Seed Extract on MCF-7 Involves Transient Increase of Gap Junction Intercellular Communication and Cx43 Up-Regulation: A Mechanism of Chemoprevention.International journal of molecular sciences · 2019Article
- A Multi-screening Evaluation of the Nutritional and Nutraceutical Potential of the Mediterranean JellyfishMarine drugs · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On a global scale, jellyfish populations in coastal marine ecosystems exhibit increasing trends of abundance. High-density outbreaks may directly or indirectly affect human economical and recreational activities, as well as public health. As the interest in biology of marine jellyfish grows, a number of jellyfish metabolites with healthy potential, such as anticancer or antioxidant activities, is increasingly reported. In this study, the Mediterranean "fried egg jellyfish" Cotylorhiza tuberculata (Macri, 1778) has been targeted in the search forputative valuable bioactive compounds. A medusa extract was obtained, fractionated, characterized by HPLC, GC-MS and SDS-PAGE and assayed for its biological activity on breast cancer cells (MCF-7) and human epidermal keratinocytes (HEKa). The composition of the jellyfish extract included photosynthetic pigments, valuable ω-3 and ω-6 fatty acids, and polypeptides derived either from jellyfish tissues and their algal symbionts. Extract fractions showed antioxidant activity and the ability to affect cell viability and intercellular communication mediated by gap junctions (GJIC) differentially in MCF-7 and HEKa cells. A significantly higher cytotoxicity and GJIC enhancement in MCF-7 compared to HEKa cells was recorded. A putative action mechanism for the anticancer bioactivity through the modulation of GJIC has been hypothesized and its nutraceutical and pharmaceutical potential was discussed.
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