ArticleBMC clinical pathology2013
Predictive value of preoperative serum CCL2, CCL18, and VEGF for the patients with gastric cancer.
Article in BMC clinical pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma.Nature communications · 2022Article
- Article
- Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes.Pathology oncology research : POR · 2021Article
- Is the C-C Motif Ligand 2-C-C Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis?International journal of molecular sciences · 2020Review
- Prediction of the treatment response in ovarian cancer: a ctDNA approach.Journal of ovarian research · 2020Review
- Systemic Reprogramming of Monocytes in Cancer.Frontiers in oncology · 2020Review
- Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients.BMC cancer · 2019Article
- High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma.Journal of Cancer · 2019Article
- Expression ofInternational journal of clinical and experimental pathology · 2019Article
- The expression of CCL18 in diffuse large B cell lymphoma and its mechanism research.Cancer biomarkers : section A of Disease markers · 2018Article
- Association of mast cell infiltration with gastric cancer progression.Oncology letters · 2018Article
- Insulin secretagogue use and circulating inflammatory C-C chemokine levels in breast cancer patients.Data in brief · 2017Article
- Increased expression of C-C motif ligand 2 associates with poor prognosis in patients with gastric cancer after gastrectomy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration.Molecular medicine reports · 2016Article
- Elevated level of some chemokines in plasma of gastric cancer patients.Central-European journal of immunology · 2016Article
- Article
- CCL18 promotes the invasion and migration of gastric cancer cells via ERK1/2/NF-κB signaling pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Circulating VEGF as a biomarker for diagnosis of ovarian cancer: a systematic review and a meta-analysis.OncoTargets and therapy · 2015Article
- Serum CCL2 and CCL3 as potential biomarkers for the diagnosis of oral squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the expression of chemokine ligand 2 (CCL2), chemokine ligand 18 (CCL18), and vascular endothelial growth factor (VEGF) in peripheral blood of patients with gastric cancer and their correlation with presence of malignancy and disease progression.
methodsSixty patients with pathological proved gastric cancer were prospectively included into study. The levels of CCL2, CCL18, and VEGF in peripheral blood were examined by enzyme-linked immunosorbentassay (ELISA). Peripheral blood from 20 healthy people was examined as control.
resultsThe preoperative serum levels of CCL2, CCL18 and VEGF in gastric cancer patients were significantly higher than that of controls (P <0.001, P <0.001, and P <0.001, respectively). ROC curve analysis showed that with a cut-off value of ≥1272.8, the VEGF*CCL2 predicted the presence of gastric cancer with 83% sensitivity and 80% specificity. Preoperative serum CCL2 was significantly correlated to N stage (P =0.040); CCL18 associated with N stage (P =0.002), and TNM stage (P =0.002); VEGF correlated to T stage (P =0.000), N stage (P =0.015), and TNM stage (P =0.000).
conclusionPreoperative serum levels of CCL2 and VEGF could play a crucial role in predicting the presence and progression of gastric cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.