ArticleEmerging infectious diseases2013
Changes in severity of influenza A(H1N1)pdm09 infection from pandemic to first postpandemic season, Germany.
Article in Emerging infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Mortality Risk Among Patients With Influenza Illness Admitted to the ICU: A Systematic Review and Meta-Analysis.Influenza and other respiratory viruses · 2025Pooled it
- Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis.BMC infectious diseases · 2019Pooled it
- Risk factors for serious outcomes associated with influenza illness in high- versus low- and middle-income countries: Systematic literature review and meta-analysis.Influenza and other respiratory viruses · 2018Pooled it
- Changes in characteristics and case-severity in patients hospitalised with influenza A (H1N1) pdm09 infection between two epidemic waves-England, 2009-2010.Influenza and other respiratory viruses · 2021Article
- Comparable Disease Severity by Influenza Virus Subtype in the Acute Respiratory Infection Consortium Natural History Study.Military medicine · 2020Article
- Characteristics of hospitalised patients with influenza in 2015-2016 in northern Israel: three circulating strains and continued fear of 2009 A/H1N1.Epidemiology and infection · 2019Article
- Factors associated with influenza vaccination failure and severe disease in a French region in 2015.PloS one · 2018Article
- Seasonal Influenza A H1N1pdm09 Virus and Severe Outcomes: A Reason for Broader Vaccination in Non-Elderly, At-Risk People.PloS one · 2016Observational
- Article
- Influenza A(H1N1)pdm09 and postpandemic influenza in Lithuania.Open medicine (Warsaw, Poland) · 2016Review
- Characterisation of nosocomial and community-acquired influenza in a large university hospital during two consecutive influenza seasons.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Observational
- Predictive Symptoms and Signs of Laboratory-confirmed Influenza: A Prospective Surveillance Study of Two Metropolitan Areas in Taiwan.Medicine · 2015Article
- Postpandemic Influenza A/H1N1pdm09 is still Causing Severe Perinatal Complications.Mediterranean journal of hematology and infectious diseases · 2015Article
- Return of pandemic H1N1 influenza virus.BMC infectious diseases · 2014Article
- Influenza and other respiratory virus infections in solid organ transplant recipients.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Review
- Epidemiology of influenza virus types and subtypes in South Africa, 2009-2012.Emerging infectious diseases · 2014Article
- Excess mortality impact of two epidemics of pandemic influenza A(H1N1pdm09) virus in Hong Kong.Influenza and other respiratory viruses · 2014Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We studied risk factors for a severe clinical outcome in hospitalized patients with laboratory-confirmed influenza A(H1N1)pdm09 infection at the University Hospital Heidelberg in the pandemic and first postpandemic seasons. We identified 102 patients in 2009-10 and 76 in 2010-11. The proportion of severely diseased patients dramatically increased from 14% in 2009-10 to 46% in 2010-11 as did the mortality rate (5%-12%). Patients in the first postpandemic season were significantly older (38 vs. 18 years) and more frequently had underlying medical conditions (75% vs. 51%). Overall, 50 patients (28%) had a severe clinical outcome, resulting in 14 deaths. Multivariate analysis showed that older male patients with chronic lung disease were at increased risk for a severe clinical outcome. In summary, the proportion of patients with severe disease and fatal cases increased in the postpandemic season. Therefore, patients with suspected infections should be promptly identified and receive early treatment.
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