ReviewBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2013
Human milk glycoproteins protect infants against human pathogens.
Review in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Factors affecting lactoferrin concentration in human milk: how much do we know?Biochemistry and cell biology = Biochimie et biologie cellulaire · 2017Pooled it
- Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates.Nutrients · 2020Trial
- Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes.Pediatric research · 2018Trial
- Trial
- Sequence-Based and Functional Analysis for the Discovery of N-Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut.MicrobiologyOpen · 2026Article
- Article
- Milk and mucin glycans orchestrate a synthetic infant gut microbiota structure.FEMS microbiology ecology · 2025Article
- Association between breastfeeding duration and educational attainment in rural Southwest Uganda: a population-based cohort study.Global health action · 2024Article
- Mammalian cell-based production of glycans, glycopeptides and glycomodules.Nature communications · 2024Article
- ExploringACS omega · 2024Article
- An anti-eCIRP strategy for necrotizing enterocolitis.Molecular medicine (Cambridge, Mass.) · 2024Article
- Labeling of Mucin-TypeACS measurement science au · 2024Article
- Impact of breastfeeding and other early-life factors on the development of the oral microbiome.Frontiers in microbiology · 2023Review
- Oral Application of Mother's Own Milk for Reducing Necrotizing Enterocolitis in Preterm Infants: An Updated Meta-Analysis of RCTs.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research.Advances in nutrition (Bethesda, Md.) · 2022Article
- Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19.Nutrients · 2022Article
- Full breastfeeding protection against common enteric bacteria and viruses: results from the MAL-ED cohort study.The American journal of clinical nutrition · 2022Article
- Lactoferrin and Immunoglobulin Concentrations in Milk of Gestational Diabetic Mothers.Nutrients · 2021Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Breastfeeding protects the neonate against pathogen infection. Major mechanisms of protection include human milk glycoconjugates functioning as soluble receptor mimetics that inhibit pathogen binding to the mucosal cell surface, prebiotic stimulation of gut colonization by favorable microbiota, immunomodulation, and as a substrate for bacterial fermentation products in the gut. Human milk proteins are predominantly glycosylated, and some biological functions of these human milk glycoproteins (HMGPs) have been reported. HMGPs range in size from 14 kDa to 2,000 kDa and include mucins, secretory immunoglobulin A, bile salt-stimulated lipase, lactoferrin, butyrophilin, lactadherin, leptin, and adiponectin. This review summarizes known biological roles of HMGPs that may contribute to the ability of human milk to protect neonates from disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.