ArticleAnnals of intensive care2013
Does vasopressor therapy have an indication in hemorrhagic shock?
Article in Annals of intensive care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04497155 (The Association of Norepinephrine Use in Pre-hospital Transport and Early Mortality in Hemorrhagic Shock), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association of Norepinephrine Use in Pre-hospital Transport and Early Mortality in Hemorrhagic Shock
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials.BioMed research international · 2014Pooled it
- Pharmacologic agents for acute hemodynamic instability: recent advances in the management of perioperative shock- a systematic review.Annals of cardiac anaesthesiaPooled it
- Comparison of Controller Logics for Automating Vasopressor Administration Using a Hardware-in-Loop Test Platform.Bioengineering (Basel, Switzerland) · 2026Article
- Effects of Vasopressin Receptor Agonists during the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Experimental and Clinical Studies.Journal of personalized medicine · 2023Article
- Association of Early Norepinephrine Administration With 24-Hour Mortality Among Patients With Blunt Trauma and Hemorrhagic Shock.JAMA network open · 2022Observational
- Effect of C-Clamp Application on Hemodynamic Instability in Polytrauma Victims with Pelvic Fracture.Medicina (Kaunas, Lithuania) · 2022Article
- Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs.Frontiers in pharmacology · 2022Article
- Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide.International journal of molecular sciences · 2021Review
- Retrospective study on rib fractures: smoking and alcohol matter for mortality and complications.Trauma surgery & acute care open · 2021Article
- Cerebral effects of resuscitation with either epinephrine or vasopressin in an animal model of hemorrhagic shock.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- The impact of early administration of vasopressor agents for the resuscitation of severe hemorrhagic shock following blunt trauma.BMC emergency medicine · 2020Article
- Article
- Evaluation of capillary leakage after vasopressin resuscitation in a hemorrhagic shock model.World journal of emergency surgery : WJES · 2018Article
- The coherence of macrocirculation, microcirculation, and tissue metabolic response during nontraumatic hemorrhagic shock in swine.Physiological reports · 2017Article
- Article
- Article
- Ilio-psoas hematoma in the intensive care unit: a multicentric study.Annals of intensive care · 2016Article
- Infrarenal aortic clamp reviving a patient from acute surgical haemorrhagic shock: a novel management technique.BMJ case reports · 2016Article
- Prehospital volume resuscitation--Did evidence defeat the crystalloid dogma? An analysis of the TraumaRegister DGU® 2002-2012.Scandinavian journal of trauma, resuscitation and emergency medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aimed to answer whether the vasopressors are useful at the early phase of hemorrhagic shock. Data were taken from published experimental studies and clinical trials. Published case reports were discarded. A search of electronic database PubMed was conducted using keywords of hemorrhagic shock, vasopressors, vasoconstrictors, norepinephrine, epinephrine, vasopressin. The redundant papers were not included. We identified 15 experimental studies that compared hemorrhagic shock resuscitated with or without vasopressors, three retrospective clinical studies, and one controlled trial. The experimental and clinical studies are discussed in the clinical context, and their strengths as well as limitations are highlighted. There is a strong rationale for a vasopressor support in severe hemorrhagic shock. However, this should be tempered by the risk of excessive vasoconstriction during such hypovolemic state. The experimental models must be analyzed within their own limits and cannot be directly translated into clinical practice. In addition, because of many biases, the results of clinical trials are debatable. Therefore, based on current information, further clinical trials comparing early vasopressor support plus fluid resuscitation versus fluid resuscitation alone are warranted.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.