ArticleBMC pharmacology & toxicology2013
Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria.
Article in BMC pharmacology & toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- A New Generation of ResNet Model Based on Artificial Intelligence and Few Data Driven and Its Construction in Image Recognition Model.Computational intelligence and neuroscience · 2022Article
- Biophysical and In-Silico Studies of Phytochemicals Targeting Chorismate Synthase from Drug-Resistant Moraxella Catarrhalis.The protein journal · 2020Article
- Review
- Sub-Inhibitory Doses of Individual Constituents of Essential Oils Can Select forMolecules (Basel, Switzerland) · 2019Article
- Methionine biosynthesis and transport are functionally redundant for the growth and virulence ofThe Journal of biological chemistry · 2018Article
- Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Antibiotics (Basel, Switzerland) · 2014Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfectious diseases are major public health problem. It is increasingly affecting more than 50 million people worldwide. Targeting shikimate pathway could be efficiently used for the development of broad spectrum antimicrobial compound against variety of infectious diseases. Chorismate synthase is an enzyme in shikimate pathway that catalyzes Phosphoenol pyruvate to chorismate in most of the prokaryotic bacteria. This step is crucial for its growth, since Chorismate acts as a precursor molecule for the synthesis of aromatic amino acids. Hence, we present a comprehensive database of Chorismate Synthase Database (CSDB) which is a manually curated database. It provides information on the sequence, structure and biological activity of chorismate synthase from shikimate pathway of pathogenic bacteria. Design of suitable inhibitors for this enzyme, hence could be a probable solution to destroy its proteomic machinery and thereby inhibit the bacterial growth. DESCRIPTION: The aim of this study was to characterise chorismate synthase enzyme belonging to pathogenic bacteria to analysis the functional and structural characterization of chorismate synthase is very important for both structure-based and ligand based drug design.
conclusionsThe broad range of data easy to use user interface makes csdb.in a useful database for researchers in designing drugs.
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