ArticlePLoS computational biology2013
Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Exploring the constituent mechanisms of hepatitis: a dynamical systems approach.Mathematical medicine and biology : a journal of the IMA · 2023Article
- Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques.Annals of biomedical engineering · 2023Review
- Step-by-step comparison of ordinary differential equation and agent-based approaches to pharmacokinetic-pharmacodynamic models.CPT: pharmacometrics & systems pharmacology · 2022Article
- Inflammatory signals and network connections implicate cell-mediated immunity in chronic venous insufficiency.Annals of translational medicine · 2021Article
- Spatial considerations in the resolution of inflammation: Elucidating leukocyte interactions via an experimentally-calibrated agent-based model.PLoS computational biology · 2020Article
- Agent-based models of inflammation in translational systems biology: A decade later.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Systematically understanding the immunity leading to CRPC progression.PLoS computational biology · 2019Article
- High-resolution computational modeling of immune responses in the gut.GigaScience · 2019Article
- Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment.Processes (Basel, Switzerland) · 2019Article
- Predicting the impact of combined therapies on myeloma cell growth using a hybrid multi-scale agent-based model.Oncotarget · 2017Article
- Mathematical and Computational Modeling in Complex Biological Systems.BioMed research international · 2017Review
- A non-invasive method to produce pressure ulcers of varying severity in a spinal cord-injured rat model.Spinal cord · 2016Article
- Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.Annals of biomedical engineering · 2016Review
- Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting.Drug discovery today. Disease models · 2016Article
- Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation.Antioxidants & redox signaling · 2015Review
- Agent-Based Modeling in Systems Pharmacology.CPT: pharmacometrics & systems pharmacology · 2015Article
- A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury.PLoS computational biology · 2015Article
- Investigating biocomplexity through the agent-based paradigm.Briefings in bioinformatics · 2015Review
- Automated parameter estimation for biological models using Bayesian statistical model checking.BMC bioinformatics · 2015Article
- Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pressure ulcers are costly and life-threatening complications for people with spinal cord injury (SCI). People with SCI also exhibit differential blood flow properties in non-ulcerated skin. We hypothesized that a computer simulation of the pressure ulcer formation process, informed by data regarding skin blood flow and reactive hyperemia in response to pressure, could provide insights into the pathogenesis and effective treatment of post-SCI pressure ulcers. Agent-Based Models (ABM) are useful in settings such as pressure ulcers, in which spatial realism is important. Ordinary Differential Equation-based (ODE) models are useful when modeling physiological phenomena such as reactive hyperemia. Accordingly, we constructed a hybrid model that combines ODEs related to blood flow along with an ABM of skin injury, inflammation, and ulcer formation. The relationship between pressure and the course of ulcer formation, as well as several other important characteristic patterns of pressure ulcer formation, was demonstrated in this model. The ODE portion of this model was calibrated to data related to blood flow following experimental pressure responses in non-injured human subjects or to data from people with SCI. This model predicted a higher propensity to form ulcers in response to pressure in people with SCI vs. non-injured control subjects, and thus may serve as novel diagnostic platform for post-SCI ulcer formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.