ArticleProceedings of the National Academy of Sciences of the United States of America2013
Blast resistance of CC-NB-LRR protein Pb1 is mediated by WRKY45 through protein-protein interaction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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108 citing papers in PubMed, 220 citations in OpenAlex.
- Functional and regulatory complexity: challenges and prospects for understanding rice WRKY transcription factors.Journal of experimental botany · 2026Review
- An LRR-truncated NLR natural variant confers dual resistance to drought and blast in rice.Nature communications · 2026Article
- Network analysis reveals that bHLH transcription factors positively regulate rice resistance to Magnaporthe oryzae.BMC plant biology · 2026Article
- WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.Plant biotechnology journal · 2026Review
- The CCCH-tandem zinc-finger protein OsTZF1 positively regulates basal immunity but suppresses Piz-t-mediated blast resistance in rice.Plant communications · 2026Article
- Soybean transcription factors GmHSF-01 and GmNF-YC03 regulate the GmSRC7BMC plant biology · 2026Article
- Blast Resistance Gene Pish Derived Reprogramming of Noncoding RNAs in Rice.Rice (New York, N.Y.) · 2026Article
- OsnTNB.11 Encodes a CC-NBS-LRR Type Resistance Protein that Positively Regulates Resistance to Rice Kernel Smut by Modulating the Ethylene Signalling.Rice (New York, N.Y.) · 2025Article
- Gene pyramiding for enhancing resistance to blast and bacterial blight disease in rice through maker assisted selection.Biotechnology letters · 2025Article
- A module with multiple transcription factors positively regulates powdery mildew resistance in grapevine.Plant biotechnology journal · 2025Article
- Gpa2 detects the potato cyst nematode effector GpRBP-1 in the cytoplasm but requires a balanced nucleocytoplasmic distribution to trigger cell death.Journal of experimental botany · 2025Article
- A century of advances in molecular genetics and breeding for sustainable resistance to rice blast disease.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease.Plants (Basel, Switzerland) · 2025Article
- OsBRW1, a novel blast-resistant gene, coded a NBS-LRR protein to interact with OsSRFP1 to balance rice growth and resistance.Plant biotechnology journal · 2025Article
- A KNOX Ⅱ transcription factor suppresses the NLR immune receptor BRG8-mediated immunity in rice.Plant communications · 2024Article
- Refinement of rice blast disease resistance QTLs and gene networks through meta-QTL analysis.Scientific reports · 2024Article
- An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function.Nature communications · 2024Article
- Transcriptome and Metabolome Analysis of Rice Cultivar CBB23 after Inoculation byPlants (Basel, Switzerland) · 2024Article
- Newly identified Pijx gene: a weapon against both seedling and panicle blast in rice.Plant cell reports · 2024Article
- Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.PloS one · 2024Article
48 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Panicle blast 1 (Pb1) is a panicle blast resistance gene derived from the indica rice cultivar "Modan." Pb1 encodes a coiled-coil-nucleotide-binding site-leucine-rich repeat (CC-NB-LRR) protein and confers durable, broad-spectrum resistance to Magnaporthe oryzae races. Here, we investigated the molecular mechanisms underlying Pb1-mediated blast resistance. The Pb1 protein interacted with WRKY45, a transcription factor involved in induced resistance via the salicylic acid signaling pathway that is regulated by the ubiquitin proteasome system. Pb1-mediated panicle blast resistance was largely compromised when WRKY45 was knocked down in a Pb1-containing rice cultivar. Leaf-blast resistance by Pb1 overexpression (Pb1-ox) was also compromised in WRKY45 knockdown/Pb1-ox rice. Blast infection induced higher accumulation of WRKY45 in Pb1-ox than in control Nipponbare rice. Overexpression of Pb1-Quad, a coiled-coil domain mutant that had weak interaction with WRKY45, resulted in significantly weaker blast resistance than that of wild-type Pb1. Overexpression of Pb1 with a nuclear export sequence failed to confer blast resistance to rice. These results suggest that the blast resistance of Pb1 depends on its interaction with WRKY45 in the nucleus. In a transient system using rice protoplasts, coexpression of Pb1 enhanced WRKY45 accumulation and increased WRKY45-dependent transactivation activity, suggesting that protection of WRKY45 from ubiquitin proteasome system degradation is possibly involved in Pb1-dependent blast resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.