ArticleThe Journal of antimicrobial chemotherapy2013
Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis.
Article in The Journal of antimicrobial chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The Status of Carbapenem Resistance in Cystic Fibrosis: A Systematic Review and Meta-Analysis.The Yale journal of biology and medicine · 2022Pooled it
- Assessing anaerobe detection in routine sputum analyses from cystic fibrosis patients.Scientific reports · 2026Article
- Refractory pneumonia caused by Prevotella heparinolytica: a case report.Journal of medical case reports · 2024Article
- Gut microbiota dysbiosis deteriorates immunoregulatory effects of tryptophan via colonic indole and LBP/HTR2B-mediated macrophage function.The ISME journal · 2024Article
- Genomic diversity and antimicrobial resistance ofMicrobial genomics · 2022Article
- Necrotizing Fasciitis Due to Prevotella denticola Infection in an Intravenous Drug User.Cureus · 2022Article
- Prevotella diversity, niches and interactions with the human host.Nature reviews. Microbiology · 2021Review
- Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2021Review
- Microbiome of Odontogenic Abscesses.Microorganisms · 2021Article
- Article
- An observational study of anaerobic bacteria in cystic fibrosis lung using culture dependant and independent approaches.Scientific reports · 2021Observational
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- Article
- Evaluation of antibiotic prescribing for adult inpatients at Sultan Qaboos University Hospital, Sultanate of Oman.European journal of hospital pharmacy : science and practice · 2018Article
- Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study.The European respiratory journal · 2018Article
- Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients.Molecular and cellular pediatrics · 2017Review
- Production of extended-spectrum β-lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota.International journal of antimicrobial agents · 2016Article
- Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery.PeerJ · 2015Article
- Article
- Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.The Journal of antimicrobial chemotherapy · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo compare the antimicrobial susceptibility of Prevotella spp. isolated from cystic fibrosis (CF) and non-CF patients and analyse the impact of antibiotic prescribing in the preceding year on resistance amongst CF isolates.
methodsThe susceptibility of 80 CF Prevotella isolates to 12 antibiotics was compared with that of 50 Prevotella isolates from invasive infections in people who did not have CF and 27 Prevotella isolates from healthy controls.
resultsAll isolates were susceptible to chloramphenicol, meropenem and piperacillin/tazobactam, with only four isolates resistant to metronidazole. However, resistance to amoxicillin, ceftazidime and tetracycline was apparent in all groups. Significant differences in clindamycin resistance (UK CF, 56%; UK invasive, 10%) and co-amoxiclav non-susceptibility (UK CF, 32%; UK invasive, 12%) were observed between UK CF and UK invasive isolates. The likelihood of non-susceptibility to clindamycin and co-amoxiclav in UK CF isolates was 5.5-fold and 2.5-fold higher relative to that in UK invasive isolates, respectively. Azithromycin MICs were also significantly higher for CF isolates (P < 0.001), which was associated with current prescription of azithromycin. More than 50% of clinical isolates tested in this study were β-lactamase positive.
conclusionsThis study profiles antibiotic susceptibility in Prevotella spp. in CF and demonstrates that meropenem, piperacillin/tazobactam, chloramphenicol and metronidazole are likely to be the most effective antibiotics if treatment is indicated.
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Registered trials
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