ArticlePlant physiology2013
The Arabidopsis RING E3 ubiquitin ligase AtAIRP3/LOG2 participates in positive regulation of high-salt and drought stress responses.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 155 citations in OpenAlex.
- CCRG1 Acts as a Downstream Effector of the Clock Proteins CCA1 and LHY to Coordinate Growth, Flowering, and Senescence.Plant, cell & environment · 2026Article
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Identification of the RING-HCa E3 Ligase Gene Family and Functional Characterization ofCurrent issues in molecular biology · 2026Article
- B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2.The New phytologist · 2025Article
- Overview of RING gene family in maize (Zea mays L.): ZmRING-93 enhances drought tolerance in transgenic Arabidopsis.BMC plant biology · 2025Article
- Lysine deacetylase TaSRT1 mediates wheat drought tolerance by deacetylating TaDT-A to reduce its protein stability and transcriptional activity.Plant biotechnology journal · 2025Article
- A system genetics analysis uncovers the regulatory variants controlling drought response in wheat.Plant biotechnology journal · 2025Article
- Review
- Arabidopsis OTU2 deubiquitinates cysteine protease RD21A to enhance clubroot resistance.The Plant journal : for cell and molecular biology · 2025Article
- Genome-wide analysis of CHYR gene family and BnA03.CHYR.1 functional verification under salt stress in Brassica napus L.BMC plant biology · 2025Article
- Multi-locus genome-wide association study for grain yield and drought tolerance indices in sorghum accessions.The plant genome · 2024Article
- Arabidopsis ubiquitin ligase PUB41 positively regulates ABA-mediated seed dormancy and drought response.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Article
- Research Progress in the Regulation of the ABA Signaling Pathway by E3 Ubiquitin Ligases in Plants.International journal of molecular sciences · 2024Review
- Comprehensive Characterization of the C3HC4 RING Finger Gene Family in Potato (International journal of molecular sciences · 2024Article
- Comparative physiological, antioxidant and proteomic investigation reveal robust response to cold stress in Digitalis purpurea L.Molecular biology reports · 2023Article
- Cosuppression of AtGELP22 and AtGELP23, two ubiquitinated target proteins of RING E3 ligase AtAIRP5, increases tolerance to drought stress in Arabidopsis.Plant molecular biology · 2023Article
- Ubiquitin E3 ligase AtCHYR2 functions in glucose regulation of germination and post-germinative growth in Arabidopsis thaliana.Plant cell reports · 2023Article
- PANTOTHENATE KINASE4, LOSS OF GDU2, and TRANSPOSON PROTEIN1 affect the canalization of tomato fruit metabolism.Plant physiology · 2023Article
- P3/P3N-PIPO of PVY interacting with BI-1 inhibits the degradation of NIb by ATG6 to facilitate virus replication inFrontiers in plant science · 2023Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Really Interesting New Gene (RING) E3 ubiquitin ligases have been implicated in cellular responses to the stress hormone abscisic acid (ABA) as well as to environmental stresses in higher plants. Here, an ABA-insensitive RING protein3 (atairp3) loss-of-function mutant line in Arabidopsis (Arabidopsis thaliana) was isolated due to its hyposensitivity to ABA during its germination stage as compared with wild-type plants. AtAIRP3 contains a single C3HC4-type RING motif, a putative myristoylation site, and a domain associated with RING2 (DAR2) domain. Unexpectedly, AtAIRP3 was identified as LOSS OF GDU2 (LOG2), which was recently shown to participate in an amino acid export system via interaction with GLUTAMINE DUMPER1. Thus, AtAIRP3 was renamed as AtAIRP3/LOG2. Transcript levels of AtAIRP3/LOG2 were up-regulated by drought, high salinity, and ABA, suggesting a role for this factor in abiotic stress responses. The atairp3/log2-2 knockout mutant and 35S:AtAIRP3-RNAi knockdown transgenic plants displayed impaired ABA-mediated seed germination and stomata closure. Cosuppression and complementation studies further supported a positive role for AtAIRP3/LOG2 in ABA responses. Suppression of AtAIRP3/LOG2 resulted in marked hypersensitive phenotypes toward high salinity and water deficit relative to wild-type plants. These results suggest that Arabidopsis RING E3 AtAIRP3/LOG2 is a positive regulator of the ABA-mediated drought and salt stress tolerance mechanism. Using yeast (Saccharomyces cerevisiae) two-hybrid, in vitro, and in vivo immunoprecipitation, cell-free protein degradation, and in vitro ubiquitination assays, RESPONSIVE TO DEHYDRATION21 was identified as a substrate protein of AtAIRP3/LOG2. Collectively, our data suggest that AtAIRP3/LOG2 plays dual functions in ABA-mediated drought stress responses and in an amino acid export pathway in Arabidopsis.
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