ReviewMolecular neurobiology2013
Regulating prefrontal cortex activation: an emerging role for the 5-HT₂A serotonin receptor in the modulation of emotion-based actions?
Review in Molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Psilocybin restores behavior and 5-HTCell reports. Medicine · 2026Article
- 5-HTZoological research · 2026Article
- Opioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A.Biomedicines · 2026Review
- 5-HT 2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats.Behavioural pharmacology · 2025Article
- Effects of psychedelic microdosing versus conventional ADHD medication use on emotion regulation, empathy, and ADHD symptoms in adults with severe ADHD symptoms: A naturalistic prospective comparison study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- DNA methylation differences in genes associated with human personal disorders and deviant behavior.AIMS neuroscience · 2024Article
- Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum.Frontiers in neural circuits · 2021Review
- Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Psychology & neuroscience · 2020Article
- The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks.Animal cognition · 2020Article
- Gene-environment interactions in antisocial behavior are mediated by early-life 5-HTNeuropharmacology · 2019Article
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Selective vulnerability of dorsal raphe-medial prefrontal cortex projection neurons to corticosterone-induced hypofunction.The European journal of neuroscience · 2019Article
- A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered womenJournal of psychiatry & neuroscience : JPN · 2019Article
- 5-HTNeuronal signaling · 2019Article
- Childhood Adversity Moderates the Effects ofFrontiers in psychiatry · 2019Article
- Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers.Development and psychopathology · 2017Article
- Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons.Brain research · 2017Article
- Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms.Psychopharmacology · 2017Article
- Emotion moderates the association between HTR2A (rs6313) genotype and antisaccade latency.Experimental brain research · 2016Article
- 5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study.Parkinson's disease · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prefrontal cortex (PFC) is involved in mediating important higher-order cognitive processes such as decision making, prompting thereby our actions. At the same time, PFC activation is strongly influenced by emotional reactions through its functional interaction with the amygdala and the striatal circuitry, areas involved in emotion and reward processing. The PFC, however, is able to modulate amygdala reactivity via a feedback loop to this area. A role for serotonin in adjusting for this circuitry of cognitive regulation of emotion has long been suggested based primarily on the positive pharmacological effect of elevating serotonin levels in anxiety regulation. Recent animal and human functional magnetic resonance studies have pointed to a specific involvement of the 5-hydroxytryptamine (5-HT)2A serotonin receptor in the PFC feedback regulatory projection onto the amygdala. This receptor is highly expressed in the prefrontal cortex areas, playing an important role in modulating cortical activity and neural oscillations (brain waves). This makes it an interesting potential pharmacological target for the treatment of neuropsychiatric modes characterized by lack of inhibitory control of emotion-based actions, such as addiction and other impulse-related behaviors. In this review, we give an overview of the 5-HT2A receptor distribution (neuronal, intracellular, and anatomical) along with its functional and physiological effect on PFC activation, and how that relates to more recent findings of a regulatory effect of the PFC on the emotional control of our actions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.