ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
SPAG9 is overexpressed in human astrocytoma and promotes cell proliferation and invasion.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 31 citations in OpenAlex.
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- Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders.Molecular neurobiology · 2021Article
- Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma.Oncology reports · 2019Article
- AKAP4, SPAG9 and NY-ESO-1 in Iranian Colorectal Cancer Patients as Probable Diagnostic and Prognostic BiomarkersAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Sperm-associated antigen 9 is upregulated in hepatocellular carcinoma tissue and enhances QGY cell proliferation and invasionOncology letters · 2018Article
- Serum levels of anti-sperm-associated antigen 9 antibody are elevated in patients with hepatocellular carcinoma.Oncology letters · 2017Article
- Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer.Oncotarget · 2016Article
- A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.Molecular oncology · 2016Article
- Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer.Oncology reports · 2016Article
- SPAG9 is involved in hepatocarcinoma cell migration and invasion via modulation of ELK1 expression.OncoTargets and therapy · 2016Article
- Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges.World journal of gastrointestinal oncology · 2015Review
- Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis.Virchows Archiv : an international journal of pathology · 2015Article
- Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.Scientific reports · 2015Article
- Overexpression of SPAG9 correlates with poor prognosis and tumor progression in hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- SPAG9 is overexpressed in human prostate cancer and promotes cancer cell proliferation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
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9 authors at 2 institutions in 1 country.
Funding
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Abstract
Sperm-associated antigen 9 (SPAG9) is a recently characterized oncoprotein involved in the progression of several human malignancies. The present study aims to investigate the expression pattern and biological roles of SPAG9 protein in human astrocytoma. SPAG9 expression was analyzed in 105 astrocytoma specimens by immunohistochemistry. We observed negative staining in normal astrocytes and positive staining of SPAG9 in 63 out of 105 (60 %) astrocytoma samples. Overexpression of SPAG9 correlated with tumor grade (p < 0.001). Small interfering RNA knockdown was performed in U251 and U87 cell lines with relatively high SPAG9 expression. Using methylthiazolyldiphenyl-tetrazolium bromide assay and Matrigel invasion assay, we were able to show that SPAG9 depletion in astrocytoma cell lines inhibited cell proliferation and invasion in both cell lines. In addition, mRNA and protein levels of matrix metallopeptidase 9 (MMP9) were downregulated, while the levels of tissue inhibitor of metalloproteinase 1 (TIMP1) and TIMP2 were not changed, indicating that SPAG9 might regulate invasion through MMP9. In conclusion, SPAG9 serves as an important oncoprotein in human astrocytoma by regulating cell proliferation and invasion.
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