ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2013
Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review.Head & neck · 2022Pooled it
- Epidemiology, prognosis, and treatment of head and neck mucoepidermoid carcinoma: a SEER-based analysis of 6228 patients (2004-2020).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Clinical features and prognostic factors of salivary adenoid cystic and mucoepidermoid carcinomas.Medicine · 2025Article
- Clinicopathological Profile and Outcomes of Mucoepidermoid Carcinoma in Sudan: Analysis of 48 Cases.Journal of maxillofacial and oral surgery · 2025Article
- Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma.Oral oncology · 2024Article
- Molecular Aspects of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Salivary Gland.Head and neck pathology · 2024Review
- Pathological Inconsistencies in Advanced Malignancies of the Parotid Gland.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Article
- Mucoepidermoid Carcinoma of the Salivary Gland: Long Term Outcomes from a Tertiary Cancer Center in India.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period.International journal of environmental research and public health · 2022Article
- Metastatic mucoepidermoid carcinoma to the pleura: a case report.Journal of medical case reports · 2022Article
- Mucoepidermoid carcinoma - A common neoplasm at an unusual site, mimicking a benign cyst on cytology: Diagnostic pitfall!Journal of oral and maxillofacial pathology : JOMFP · 2022Article
- Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.Oral oncology · 2021Article
- Mucoepidermoid carcinoma of the lacrimal gland in a patient with theRadiology case reports · 2021Article
- Poorly differentiated mucoepidermoid carcinoma of the thyroid.BMJ case reports · 2020Article
- Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment.Cancers · 2020Review
- Prognostic Nomograms for Predicting Overall Survival and Cancer-Specific Survival of Patients with Major Salivary Gland Mucoepidermoid Carcinoma.Journal of Cancer · 2019Article
- Mucoepidermoid Carcinoma of the Salivary Glands: Survival and Prognostic Factors.Journal of maxillofacial and oral surgery · 2017Article
- Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.Oral oncology · 2017Article
- Prognostic factors of palatal mucoepidermoid carcinoma: a retrospective analysis based on a double-center study.Scientific reports · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo describe the epidemiology and determine the clinicopathologic predictors of recurrence and survival in patients with head and neck mucoepidermoid carcinoma (MEC). STUDY
designCase series with chart review.
settingTertiary care hospital. SUBJECTS AND
methodsThe medical records of 101 patients who underwent surgical treatment at the University of Michigan for head and neck MEC between 1985 and 2010 were reviewed. Main outcome measures were disease-free survival (DFS), disease-specific survival (DSS), and overall survival. Clinicopathologic parameters evaluated were age, sex, subsite, histological grade, adjuvant therapy, T stage, nodal status with/without extracapsular spread, and margin status.
resultsOf the 101 patients, 38 parotid, 33 palate, 17 oral, 8 submandibular/sublingual, 4 orbital, and 1 parapharyngeal carcinomas were identified. All patients underwent surgical resection, 23 had postoperative radiation, and 2 had postoperative chemoradiation. The 5-year OS and DSS was 79% and 95% with a median follow-up of 72 and 45 months, respectively. Five-year DFS was 76%. On univariate analysis, histological grade was a statistically significant predictor of disease-free survival (P = .001) and overall survival (P = .04). Positive nodal status was a significant predictor of DSS (P = .004). There was no statistically significant difference in DFS, DSS, or OS based on sex, age, anatomic subsite, T stage, adjuvant therapy, and margin status.
conclusionAdvanced histological grade and positive nodal status are the strongest independent predictors of prognosis in head and neck MEC patients. Further studies into the molecular biology of MEC that may account for such clinicopathological features are currently underway.
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