ArticleSurgery today2014
Severe postoperative hemorrhage caused by antibody-mediated coagulation factor deficiencies: report of two cases.
Article in Surgery today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Acquired hemophilia A secondary to cholangiocarcinoma: A case report and literature review.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- A case of acquired hemophilia A after pancreaticoduodenectomy for distal cholangiocarcinoma.Biomedical reports · 2023Article
- Acquired hemophilia A developing in the perioperative period of pancreatoduodenectomy: a report of two cases.Surgical case reports · 2023Article
- Confusing delayed hematemesis, unusual arterial hemorrhage after pancreaticoduodenectomy: a case report.The Journal of international medical research · 2022Article
- Recurrent bleeding after rubber band ligation diagnosed as mild hemophilia B: a case report and literature review.BMC surgery · 2022Review
- Surgery-associated acquired hemophilia A: a report of 2 cases and review of literature.BMC surgery · 2020Review
- "The Immune Conundrum": Acquired Hemophilia A, Immune Thrombocytopenia, and Neutropenia in a Patient with Pancreatic Cancer.Case reports in pancreatic cancer · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibody-mediated coagulation factor deficiencies constitute a rare disorder that may develop in elderly patients without any history of a bleeding diathesis. Patients may present with severe and sometimes catastrophic bleeding. We report two cases of postoperative hemorrhage caused by a coagulation factor deficiency. In Case 1, massive intraabdominal bleeding occurred on day 3 after pancreaticoduodenectomy for bile duct cancer, and was caused by an acquired inhibitor of coagulation factor VIII. Hemostasis was achieved and the factor VIII inhibitor titer decreased to zero with activated prothrombin complex concentrates, prednisolone, and cyclophosphamide. In Case 2, intraabdominal bleeding occurred on day 7 after hepatectomy for hepatocellular carcinoma, and was caused by an acquired inhibitor against factors II (prothrombin) and V. This patient was treated with hemostatic agents containing bovine thrombin during surgery and also with prednisolone. We report these cases to highlight that antibody-mediated coagulation factor deficiencies should be considered when an elderly patient suffers sudden postoperative hemorrhage and to stress the importance of prompt diagnosis because of the risk of potentially life-threatening hemorrhage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.