ArticleEuropean journal of human genetics : EJHG2013
Secondary variants--in defense of a more fitting term in the incidental findings debate.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Pooled it
- A systematic approach to the disclosure of genomic findings in clinical practice and research: a proposed framework with colored matrix and decision-making pathways.BMC medical ethics · 2021Article
- The impact of unsolicited findings in clinical exome sequencing, a qualitative interview study.European journal of human genetics : EJHG · 2021Article
- Incidental or secondary findings: an integrative and patient-inclusive approach to the current debate.European journal of human genetics : EJHG · 2018Article
- Points to consider for laboratories reporting results from diagnostic genomic sequencing.European journal of human genetics : EJHG · 2018Article
- Effect of Public Deliberation on Attitudes toward Return of Secondary Results in Genomic Sequencing.Journal of genetic counseling · 2017Article
- Is "incidental finding" the best term?: a study of patients' preferences.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing.European journal of human genetics : EJHG · 2016Article
- Genome-Wide Sequencing for Prenatal Detection of Fetal Single-Gene Disorders.Cold Spring Harbor perspectives in medicine · 2015Review
- Ethical signposts for clinical geneticists in secondary variant and incidental finding disclosure discussions.Medicine, health care, and philosophy · 2015Article
- A more fitting term in the incidental findings debate: one term does not fit all situations.European journal of human genetics : EJHG · 2014Article
- The unintended implications of blurring the line between research and clinical care in a genomic age.Personalized medicine · 2014Article
- A framework for analyzing the ethics of disclosing genetic research findings.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2014Article
- Incidental Findings with Genomic Testing: Implications for Genetic Counseling Practice.Current genetic medicine reportsReview
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New genetic technologies are capable of returning far more information than the single answer to the single question posed when conducting a given genetic test. Genetics contexts consequently stand on the brink of an explosion of what have traditionally been called 'incidental findings'. However, the continued use of this term is controversial. Various replacements for 'incidental findings' have been attempted, but none with widespread success. Agreement on terminology and definitions is vital so that the legal and ethical debate around incidental findings can proceed. We highlight the difficulties raised by the various terms currently used as alternatives, and end by defending our choice for the term 'secondary variants'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.