ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Controversies in migraine treatment: opioids should be avoided.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Diagnostic approach and management of patients with headache in Danish chiropractic practice.Chiropractic & manual therapies · 2026Article
- Opioid Use among People with Migraine: Results of the OVERCOME (US) Study.Pain and therapy · 2025Article
- Intergroup time bias and aversive racism in the medical context.Journal of personality and social psychology · 2024Article
- Potentially Inappropriate Use of Opioids in the Management of Migraine in Colombia.Biomedicines · 2023Article
- Impact of an Educational Intervention on the Opioid Knowledge and Prescribing Behaviors of Resident Physicians.Cureus · 2022Article
- Effectiveness of erenumab and onabotulinumtoxinA on acute medication usage and health care resource utilization as migraine prevention in the United States.Journal of managed care & specialty pharmacy · 2021Article
- Article
- Opioid Use to Treat Migraine Headaches in Hospitalized Children and Adolescents.Hospital pediatrics · 2020Article
- Article
- Management of Childhood Headache in the Emergency Department. Review of the Literature.Frontiers in neurology · 2019Review
- Review
- Article
- Factors Associated with Direct Health Care Costs Among Patients with Migraine.Journal of managed care & specialty pharmacy · 2017Observational
- Drug Interaction and Serotonin Toxicity with Opioid Use: Another Reason to Avoid Opioids in Headache and Migraine Treatment.Current pain and headache reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of opioids for migraine is still controversial. Evidence-based guidelines do not recommend opioids as first-line treatment of migraine attacks, while clinical and epidemiological surveys demonstrate that the use of opioids is associated with more severe headache-related disability, symptomology and comorbidities, and greater health-care resource utilization. There are concerns that opioids may be misused or abused, leading to opioid abuse or dependence and migraineurs are particularly prone and at risk for the development of chronic daily headache from opioids overuse. Since clinical and preclinical studies evidence a pathophysiological role of opioids in migraine progression, opioids should be avoided in migraine patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.