Trial reportThe journal of trauma and acute care surgery2013
Amino acid infusion fails to stimulate skeletal muscle protein synthesis up to 1 year after injury in children with severe burns.
Trial report in The journal of trauma and acute care surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Predictors of muscle protein synthesis after severe pediatric burns.The journal of trauma and acute care surgery · 2015Trial
- Early rehabilitative exercise training in the recovery from pediatric burn.Medicine and science in sports and exercise · 2014Trial
- Effects of Different Ratios of Carbohydrate-Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats.Nutrients · 2022Article
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- The impact of catecholamines on skeletal muscle following massive burns: Friend or foe?Burns : journal of the International Society for Burn Injuries · 2021Review
- Current problems in burn hypermetabolism.Current problems in surgery · 2020Review
- Determinants of skeletal muscle protein turnover following severe burn trauma in children.Clinical nutrition (Edinburgh, Scotland) · 2019Observational
- Dysregulated Handling of Dietary Protein and Muscle Protein Synthesis After Mixed-Meal Ingestion in Maintenance Hemodialysis Patients.Kidney international reports · 2018Article
- The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- Article
- Amino Acid Sensing in Skeletal Muscle.Trends in endocrinology and metabolism: TEM · 2016Review
- Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.American journal of physiology. Endocrinology and metabolism · 2016Article
- Skeletal Muscle Protein Breakdown Remains Elevated in Pediatric Burn Survivors up to One-Year Post-Injury.Shock (Augusta, Ga.) · 2015Article
- Third-degree hindpaw burn injury induced apoptosis of lumbar spinal cord ventral horn motor neurons and sciatic nerve and muscle atrophy in rats.BioMed research international · 2015Article
- The role of exercise in the rehabilitation of patients with severe burns.Exercise and sport sciences reviews · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundBurn injury results in increased skeletal muscle protein turnover, where the magnitude of protein breakdown outweighs synthesis, resulting in muscle wasting. The effect of increased amino acid (AA) provision on skeletal muscle fractional synthesis rate (FSR) in severely burned patients during their convalescence after discharge from hospital is not known. Subsequently, the purpose of this study was to determine skeletal muscle FSR in response to AA infusion in severely burned pediatric patients at discharge from hospital and at 6 and 12 months after injury.
methodsStable isotope infusion studies were performed in the fasted state and during intravenous AA infusion. Skeletal muscle biopsies were obtained and isotope enrichment was determined to calculate skeletal muscle FSR. Patients were studied at discharge from hospital (n = 11) and at 6 (n = 15) and 12 months (n = 14) after injury.
resultsThe cohorts of patients studied at each time point after injury were not different with regard to age, body mass, or burn size. AA infusion failed to stimulate FSR above basal values at discharge from hospital (mean [SEM]: 0.27% [0.04%] vs. 0.26% [0.06%] per hour), 6 months after injury (0.20% [0.04%] vs. 0.22% [0.03%] per hour), and 12 months after injury (0.16% [0.03%] vs. 0.15% [0.03%] per hour). Daily FSR was numerically lower at 6 months after burn (5.13% [0.78%] per day) and significantly (p < 0.05) lower at 12 months after burn (3.67% [0.65%] per day) relative to discharge group (6.32% [1.02%] per day). DISCUSSION: The findings of the current study suggest that the deleterious effect of burn injury on skeletal muscle AA metabolism persists for up to 1 year post burn. In light of these findings, nutritional and pharmacological strategies aimed at attenuating muscle protein breakdown post burn may be a more efficacious approach to maintaining muscle mass in severely burned patients. LEVEL OF EVIDENCE: Prognostic study, level II.
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