ArticlePsychiatry research2013
Prenatal cocaine exposure alters functional activation in the ventral prefrontal cortex and its structural connectivity with the amygdala.
Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Lutein administration during gestation protects morphine withdrawal-induced on reflexive motor behavior in mice offspring's.Heliyon · 2025Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC.Translational psychiatry · 2023Article
- An intergenerational lifespan perspective on the neuroscience of prenatal substance exposure.Pharmacology, biochemistry, and behavior · 2022Article
- The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users.Addiction biology · 2022Article
- Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis.Translational psychiatry · 2021Article
- Preserving Right Pre-motor and Posterior Prefrontal Cortices Contribute to Maintaining Overall Basic Emotion.Frontiers in human neuroscience · 2021Article
- Oscillatory Dynamics of Feedback Processing in Adolescents with Prenatal Cocaine Exposure.Developmental neuropsychology · 2019Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging.Drug and alcohol dependence · 2019Review
- Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.Drug and alcohol dependence · 2017Article
- Developmental Connectomics from Infancy through Early Childhood.Trends in neurosciences · 2017Review
- Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo.Human brain mapping · 2017Article
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2017Article
- Functional Connectivity of the Infant Human Brain: Plastic and Modifiable.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2017Review
- Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users.Human brain mapping · 2015Article
- Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study.Drug and alcohol dependence · 2015Article
- Prenatal drug exposure affects neonatal brain functional connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Prenatal cocaine exposure (PCE) is associated with arousal dysregulation, and alterations of amygdala activity in response to emotional arousal have previously been reported. However, voluntary regulation of emotional affect, enabling appropriate neural response to different streams of stimuli, must also engage prefrontal regions, yet the impact of PCE on these prefrontal mechanisms has not been investigated. Recent neuroimaging studies have shown the involvement of ventral prefrontal cortex (vPFC) in the modulation of amygdala reactivity and the mediation of effective emotional regulation. Based on these findings, using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), the present study compared functional activations of the vPFC as well as its structural connectivity with the amygdala between groups of PCE and control adolescents. In a working memory task with emotional distracters, the PCE adolescents exhibited less capability of increasing their vPFC activation in response to increased memory load, which corresponded with their less suppressed amygdala activation. Reduced structural connectivity between the vPFC and the amygdala was also observed from DTI measurement in the PCE group. In addition, correlations between amygdala activation and (i) vPFC activation, as well as (ii) amygdala-vPFC structural connectivity, were observed in the control but not in the PCE group. These data complement previous findings of the impact of PCE on the activity of the amygdala and extend our understanding of the neurobiological mechanisms underlying the effect of PCE on arousal dysregulation reported in human and animal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.