ArticleBMC infectious diseases2013
Soluble CD163 does not predict first-time myocardial infarction in patients infected with human immunodeficiency virus: a nested case-control study.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Inflammatory Biomarkers Predicting Major Adverse Cardiovascular Events in People Living With HIV: A Systematic Review and Meta-Analysis.Journal of the International AIDS Society · 2026Pooled it
- Pro-Inflammatory Markers in Relation to Cardiovascular Disease in HIV Infection. A Systematic Review.PloS one · 2016Pooled it
- Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection.Cellular & molecular immunology · 2015Trial
- Multiple substance use, inflammation and cardiac stretch in women living with HIV.Drug and alcohol dependence · 2022Article
- Residual immune activation in HIV-Infected individuals expands monocytic-myeloid derived suppressor cells.Cellular immunology · 2021Article
- Clinical significance of sCD163 and its possible role in asthma (Review).Molecular medicine reports · 2017Review
- Pre-clinical carotid atherosclerosis and sCD163 among virally suppressed HIV patients in Botswana compared with uninfected controls.PloS one · 2017Article
- Article
- Role of immune activation in progression to AIDS.Current opinion in HIV and AIDS · 2016Review
- Elevated levels of monocyte activation markers are associated with subclinical atherosclerosis in men with and those without HIV infection.The Journal of infectious diseases · 2015Observational
- The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals.Journal of translational medicine · 2015Article
- Influence of immune activation and inflammatory response on cardiovascular risk associated with the human immunodeficiency virus.Vascular health and risk management · 2015Review
- Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoluble CD163 (sCD163) has been associated with arterial inflammation and non-calcified plaques in human immunodeficiency virus (HIV)-infected individuals and has therefore been suggested as a predictive biomarker of myocardial infarction (MI).
methodsWe conducted a nested case-control study of 55 cases with first-time MI and 182 controls matched for age, duration of antiretroviral therapy (ART), gender, smoking, and no known cardiovascular disease. All patients had four available plasma samples, 1: Before initiation of antiretroviral therapy (ART), 2: Three months after ART, 3: One year before the case's MI, and 4: The last sample available before the case's MI. We used conditional logistic regression to estimate the association of sCD163 with first-time MI.
resultsThe two groups had similar HIV-parameters and cardiovascular risk factors were equally distributed. There was no significant association between sCD163 and MI neither in samples obtained one year before (OR 1.05, CI 95% 0.85 - 1.29, p = 0.66) nor two months before (OR 1.20, CI 95% 0.98-1.47 p = 0.08).
conclusionsCD163 did not prove to be a useful biomarker for prediction of first-time MI in a HIV-infected population.
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