ReviewBioMed research international2013
Improved succinate production by metabolic engineering.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 120 citations in OpenAlex.
- Extracellular Succinate Modulates Neuroimmune Responses in a Murine Microglial Cell Line.Biomolecules · 2026Article
- Review
- Article
- Recent advances in genetic engineering and chemical production in yeast species.FEMS yeast research · 2025Review
- Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study.Human genomics · 2024Article
- Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases.iMeta · 2023Review
- OptEnvelope: A target point guided method for growth-coupled production using knockouts.PloS one · 2023Article
- Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- A hybrid of Bees algorithm and regulatory on/off minimization for optimizing lactate and succinate production.Journal of integrative bioinformatics · 2022Article
- Valorisation of xylose to renewable fuels and chemicals, an essential step in augmenting the commercial viability of lignocellulosic biorefineries.Sustainable energy & fuels · 2021Review
- Enhancement of β-Alanine Biosynthesis inBiology · 2021Article
- Article
- Strain engineering and bioprocessing strategies for biobased production of porphobilinogen inBioresources and bioprocessing · 2021Article
- A Genomic Perspective on the Potential of Wild-Type Rumen BacteriumInternational journal of molecular sciences · 2020Article
- Comparison of pathway analysis and constraint-based methods for cell factory design.BMC bioinformatics · 2019Article
- Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z.BMC systems biology · 2018Article
- Rate-limiting steps in the Saccharomyces cerevisiae ergosterol pathway: towards improved ergosta-5,7-dien-3β-ol accumulation by metabolic engineering.World journal of microbiology & biotechnology · 2018Article
- Intracellular product recycling in high succinic acid producing yeast at low pH.Microbial cell factories · 2017Article
- Influence of whole-wheat consumption on fecal microbial community structure of obese diabetic mice.PeerJ · 2016Article
- Systematic engineering of pentose phosphate pathway improvesBiotechnology for biofuels · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Succinate is a promising chemical which has wide applications and can be produced by biological route. The history of the biosuccinate production shows that the joint effort of different metabolic engineering approaches brings successful results. In order to enhance the succinate production, multiple metabolical strategies have been sought. In this review, different overproducers for succinate production, including natural succinate overproducers and metabolic engineered overproducers, are examined and the metabolic engineering strategies and performances are discussed. Modification of the mechanism of substrate transportation, knocking-out genes responsible for by-products accumulation, overexpression of the genes directly involved in the pathway, and improvement of internal NADH and ATP formation are some of the strategies applied. Combination of the appropriate genes from homologous and heterologous hosts, extension of substrate, integrated production of succinate, and other high-value-added products are expected to bring a desired objective of producing succinate from renewable resources economically and efficiently.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.