ReviewNeural plasticity2013
Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy.
Review in Neural plasticity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour.Molecular psychiatry · 2023Pooled it
- Body Processing in Children and Adolescents with Traumatic Brain Injury: An Exploratory Study.Brain sciences · 2022Article
- Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice.Environmental toxicology · 2022Article
- Practice patterns and recommendations for pediatric image-guided radiotherapy: A Children's Oncology Group report.Pediatric blood & cancer · 2020Article
- Pilot study of neurologic toxicity in mice after proton minibeam therapy.Scientific reports · 2020Article
- Consistent Physical Activity and Future Neurocognitive Problems in Adult Survivors of Childhood Cancers: A Report From the Childhood Cancer Survivor Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Effects of supratentorial and infratentorial tumor location on cognitive functioning of children with brain tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Late Side Effects in Normal Mouse Brain Tissue After Proton Irradiation.Frontiers in oncology · 2020Article
- Born this way: Hippocampal neurogenesis across the lifespan.Aging cell · 2019Review
- Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.Scientific reports · 2019Article
- Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target.Scientific reports · 2019Article
- Selective Neural Deletion of theFrontiers in cellular neuroscience · 2019Article
- Particle Radiation Induced Neurotoxicity in the Central Nervous System.International journal of particle therapy · 2018Review
- Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators.Translational psychiatry · 2017Review
- Functional MRI in medulloblastoma survivors supports prophylactic reading intervention during tumor treatment.Brain imaging and behavior · 2016Article
- Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus.Neural plasticity · 2016Article
- Adolescent and young adult patients with cancer: a milieu of unique features.Nature reviews. Clinical oncology · 2015Review
- Minibeam therapy with protons and light ions: physical feasibility and potential to reduce radiation side effects and to facilitate hypofractionation.International journal of radiation oncology, biology, physics · 2015Article
- Charged Particle Therapy with Mini-Segmented Beams.Frontiers in oncology · 2015Article
- Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.Radiation oncology (London, England) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive "late" effects that may take years to fully manifest. These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT. Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex), while chronic inflammation and dearth of trophic substances (such as growth hormone) limit neuroplastic potential in existing circuitry. Potential treatments for cognitive late effects should address both of these conditions. Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity. Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.