ArticlePloS one2013
Altered hub configurations within default mode network following acupuncture at ST36: a multimodal investigation combining fMRI and MEG.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Activities Responding to Acupuncture at ST36 (Frontiers in neurology · 2022Pooled it
- Magnetoencephalography study of the Xingnao Kaiqiao acupuncture during acupuncture and language task states in healthy volunteers: a single-blind, randomized, sham-controlled trial protocol.Frontiers in neurology · 2026Article
- Dynamic EEG network responses to acupuncture stimulation in patients with stroke: a neurophysiological study.Frontiers in neuroscience · 2026Article
- Acupuncture at Zusanli (ST36) for the benefits of sepsis-laboratory evidence for "preventive treatment of disease" and "holistic concept" in the protective effects of acupuncture: a literature review of rodent studies.Frontiers in neurology · 2025Review
- Recognition of flight cadets brain functional magnetic resonance imaging data based on machine learning analysis.PloS one · 2025Article
- Research status and trends of functional magnetic resonance imaging technology in the field of acupuncture: a bibliometric analysis over the past two decades.Frontiers in neuroscience · 2025Review
- Exploring the potential central regulatory mechanisms of acupuncture for acute-stage Bell's palsy: an fMRI-based investigation.Frontiers in neuroscience · 2025Article
- Article
- The Involvement of the Ventral Tegmental Area in the Electroacupuncture Alleviation of Anxiety-Like Behaviors Induced by Chronic Restraint Stress in Mice.Neurochemical research · 2024Article
- Acupuncture decreases amygdala functional connectivity in subjective tinnitus.Frontiers in neurology · 2022Article
- Article
- Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity.Scientific reports · 2021Article
- IMAGING OF BRAIN FUNCTION BASED ON THE ANALYSIS OF FUNCTIONAL CONNECTIVITY - IMAGING ANALYSIS OF BRAIN FUNCTION BY FMRI AFTER ACUPUNCTURE AT LR3 IN HEALTHY INDIVIDUALS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- The Status of the Quality Control in Acupuncture-Neuroimaging Studies.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Sustained Effects of Acupuncture Stimulation Investigated with Centrality Mapping Analysis.Frontiers in human neuroscience · 2016Article
- Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging.Neural regeneration research · 2015Article
- Specific Correlation between the Hegu Point (LI4) and the Orofacial Part: Evidence from an fMRI Study.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Neuroimaging and Neuromonitoring Effects of Electro and Manual Acupuncture on the Central Nervous System: A Literature Review and Analysis.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients.The journal of headache and pain · 2015Article
- Graph theoretical analysis of resting-state MEG data: Identifying interhemispheric connectivity and the default mode.NeuroImage · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Acupuncture, an externally somatosensory stimulation in the Traditional Chinese Medicine, has been proposed about its modulations on the brain's default mode network (DMN). However, it is still unknown on how the internal brain resting networks are modulated and what inferences can be made about the physiological processes underlying these changes. Combining high spatial resolution of functional magnetic resonance imaging (fMRI) with high temporal resolution of magnetoencephalography (MEG), in the current multimodal study, we sought to explore spatiotemporally whether or not band-specific DMN hub configurations would be induced by verum acupuncture, compared with sham control. Spatial independent component analysis was applied to fMRI data, followed by the discrete regional sources seeded into MEG data. Partial correlation analysis was further adopted to estimate the intrinsic functional connectivity and network hub configurations. One of the most striking findings is that the posterior cingulate cortex is not only validated as a robust DMN hub, but served as a hub only within the delta and gamma bands following the verum acupuncture, compared with its consistently being a DMN hub in sham control group. Our preliminary results may provide a new perspective to lend support for the specificity of neural mechanism underlying acupuncture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.